8-羟基脱氧鸟苷作为DNA氧化损伤标志物在疾病诊断中的应用

被引：38

作者：

高玉楠 ^{[1
]}

杨靖 ^{[1
]}

宋沁馨 ^{[1
,2
]}

李博 ^{[1
,2
]}

陈国华 ^{[3
]}

丁黎 ^{[1
,2
]}

机构：

[1] 中国药科大学药物分析教研室

[2] 中国药科大学药物质量与安全预警教育部重点实验室

[3] 中国药科大学药物化学教研室

来源：

药学与临床研究 | 2012年 / 20卷 / 03期

关键词：

8-羟基脱氧鸟苷; 氧化损伤; 生物标志物; 糖尿病; 癌症; 心血管疾病;

D O I：

10.13664/j.cnki.pcr.2012.03.015

中图分类号：

R440 [];

学科分类号：

100208 ;

摘要：

机体内,活性氧簇(reactive oxygen species,ROS)过度蓄积可造成DNA氧化损伤,产生8-羟基脱氧鸟苷(8-hydroxy-2′-deoxyguanosine,8-OHdG)。多项研究表明,8-OHdG不仅反映整个机体平均的氧化损伤率及体内DNA氧化损伤与机体正常的修复作用,而且与糖尿病、癌症、心血管疾病的发生和病情发展有着密切的关系。本文对8-OHdG作为氧化损伤标志物在糖尿病及其并发症、癌症、心血管疾病的诊断及治疗评价中的应用进行了综述,认为8-OHdG可能成为氧化应激相关疾病的一种极有前途的生物标志物。

引用

页码：223 / 228

页数：6

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