以糖代谢为靶向的肿瘤治疗研究进展

被引：6

作者：

王烟 ^{[1
]}

张丽丽 ^{[1
]}

曾林川 ^{[1
]}

李质馨 ^{[2
]}

徐冶 ^{[3
]}

机构：

[1] 吉林医药学院公共卫生学院

[2] 吉林医药学院组织学与胚胎学教研室

[3] 吉林医药学院医学科研实验室

来源：

吉林医药学院学报 | 2016年 / 37卷 / 05期

关键词：

肿瘤; 糖代谢; 靶点;

D O I：

10.13845/j.cnki.issn1673-2995.2016.05.022

中图分类号：

R730.5 [肿瘤治疗学];

学科分类号：

100214 [肿瘤学];

摘要：

恶性肿瘤细胞和正常细胞之间的糖代谢存在本质上的差异。在常氧条件下,正常细胞通过氧化磷酸化产生ATP,而肿瘤细胞高度依赖糖酵解。全面了解肿瘤细胞独特的糖代谢方式将有助于寻找以糖代谢途径为靶点的更有效的肿瘤治疗药物,这将对肿瘤治疗效果的提高产生极大的影响。本文对瓦伯格效应(Warburg effect)在肿瘤中的作用、以糖酵解途径作为肿瘤治疗靶标研究以及以氧化磷酸化途径为靶点的进展作一阐述。

引用

页码：372 / 374

页数：3

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