氧化应激在慢性阻塞性肺疾病发生中的作用及防治策略

被引：14

作者：

付玥川 ^{[1
]}

丁婕 ^{[1
]}

邓炯 ^{[2
,3
,4
]}

机构：

[1] 上海交通大学医学院

[2] 上海交通大学医学院病理生理系细胞分化与凋亡教育部重点实验室

[3] 肿瘤微环境与炎症上海市重点实验室

[4] 上海胸科医院转化医学中心

来源：

国际呼吸杂志 | 2016年 / 36卷 / 02期

关键词：

吸烟; 氧化应激; 慢性阻塞性肺疾病;

D O I：

暂无

中图分类号：

R563.9 [其他];

学科分类号：

100201 [内科学];

摘要：

COPD特征是慢性气道炎症、细小支气管重塑及肺实质破坏。研究表明, 香烟烟雾等有害气体所引起的氧化应激在COPD发展过程起到了至关重要的作用。吸烟增强氧化应激, 使氧化/抗氧化比例失衡, 直接损伤肺组织, 加重气道炎症反应, 引起自身免疫反应, 最终导致气流受限。因此, 对抗氧化应激、提高宿主抗氧化能力, 是COPD防治的最新着重点。

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