他汀类药物非降脂作用机制

Diseasefree intervals after partial ileal bypass in patients with coronary heart disease and hypercholesterolemia: report from the program on the surgical control of the hyperlipidemias ( POSCH). Buchwald H,Campos CT,Boen JR,et al. Journal of the American College of Cardiology . 1995

Levels of soluble cell adhesion moecules in patients with dyslipidemia. Hackman A,Abe Y,Insull W Jr,et al. Circulation . 1996

Structrual basis for LFA-1 inhibition upon lovastatin binding to the cd11a I-domain. Kallen J,Welzenbach K,Ramage P,et al. Molecular Biology . 1999

Elucidation of the role of plaque instability and rupture in acute in acute coronary events. Fuster V. The American Journal of Cardiology . 1995

Platelet cytosolic Ca2+ and membrane dynamics in patients with primary hypercholesterolemia.Effects of pravastatin. Le Quan,Sang KH,Levenson J,et al. Arteriosclerosis and Thrombosis .

HMG-CoA reductase inhibitors decrease CD11b expression and CD11b-dependent adhesion of monocytes to endothelium and reduce increased adhesiveness of monocytes isolaed from patients with hypercholesterolemia. Weber C,Erl W,Weber KS,et al. Journal of the American College of Cardiology . 1997

Upregulation of endothelial nitric oxide synthase by HMG CoA reductase inhibitors. Laufs U,La Fata V,Plutzky J,et al. Circulation . 1998

Lovastatin therapy in hypercholesterolemia: effect on fibrinogen, hemorrheologic paramentrs, platelet activity, and red blood cell morphology. Beigel Y,Fuchs J,Snnir M,et al. Journal of Clinical Pharmacology . 1991

Effects of hydroxymethylglutaryl coenzyme A reductase inhititor simvastatin on smooth muscle cell proliferation in vitro and neointimal formation in vivo after vascular injury. Indolfi C,Cioppa A,Stabile E,et al. Journal of the American College of Cardiology . 2000

Randomized placebo-controlled study of the effects of simvastatin on haemostatic varibales,lipoproteins and free acids.The oxford cholesterol study group. Mitropoulos KA,Armitage JM,Collins R,et al. European Heart Journal . 1997

Diseasefree intervals after partial ileal bypass in patients with coronary heart disease and hypercholesterolemia: report from the program on the surgical control of the hyperlipidemias ( POSCH). Buchwald H,Campos CT,Boen JR,et al. Journal of the American College of Cardiology . 1995

Levels of soluble cell adhesion moecules in patients with dyslipidemia. Hackman A,Abe Y,Insull W Jr,et al. Circulation . 1996

Structrual basis for LFA-1 inhibition upon lovastatin binding to the cd11a I-domain. Kallen J,Welzenbach K,Ramage P,et al. Molecular Biology . 1999

Elucidation of the role of plaque instability and rupture in acute in acute coronary events. Fuster V. The American Journal of Cardiology . 1995

Platelet cytosolic Ca2+ and membrane dynamics in patients with primary hypercholesterolemia.Effects of pravastatin. Le Quan,Sang KH,Levenson J,et al. Arteriosclerosis and Thrombosis .

HMG-CoA reductase inhibitors decrease CD11b expression and CD11b-dependent adhesion of monocytes to endothelium and reduce increased adhesiveness of monocytes isolaed from patients with hypercholesterolemia. Weber C,Erl W,Weber KS,et al. Journal of the American College of Cardiology . 1997

Upregulation of endothelial nitric oxide synthase by HMG CoA reductase inhibitors. Laufs U,La Fata V,Plutzky J,et al. Circulation . 1998

Lovastatin therapy in hypercholesterolemia: effect on fibrinogen, hemorrheologic paramentrs, platelet activity, and red blood cell morphology. Beigel Y,Fuchs J,Snnir M,et al. Journal of Clinical Pharmacology . 1991

Effects of hydroxymethylglutaryl coenzyme A reductase inhititor simvastatin on smooth muscle cell proliferation in vitro and neointimal formation in vivo after vascular injury. Indolfi C,Cioppa A,Stabile E,et al. Journal of the American College of Cardiology . 2000

Randomized placebo-controlled study of the effects of simvastatin on haemostatic varibales,lipoproteins and free acids.The oxford cholesterol study group. Mitropoulos KA,Armitage JM,Collins R,et al. European Heart Journal . 1997