白细胞介素-27与自身免疫病的研究进展

被引:3
作者
张璐
李霞
孙凌云
机构
[1] 南京医科大学附属鼓楼临床医学院风湿免疫科
关键词
D O I
暂无
中图分类号
R593.2 [自身免疫性疾病、结缔组织疾病];
学科分类号
100201 [内科学];
摘要
<正>白细胞介素(interleukin,IL)-27是2002年首先报道的一种新型细胞因子。IL-27属于IL-12/IL-6细胞因子家族,该家族细胞因子均为异源二聚体,其受体含有促红细胞生成素受体结构域。IL-27有着促炎和抑炎双向免疫调节作用,在感染、自身免疫病和肿瘤的发生发展中发挥了一定作用。1 IL-27的生物学特性和其他IL-12/IL-6家族成员一样,IL-27主要由p28和EB病毒诱导蛋白3(EBI3)两个亚基组成,分别与IL-12的
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