白三烯受体拮抗剂的抗炎作用机制

被引:36
作者
武玉清
机构
[1] 扬州大学医药研究所
关键词
白三烯受体拮抗剂; 炎症; 免疫;
D O I
暂无
中图分类号
R96 [药理学];
学科分类号
100602 ; 100706 ;
摘要
白三烯受体拮抗剂 (LTRAs)是近年来发展起来的一类新型非类固醇类平喘和抗炎药 ,国外已用来治疗哮喘并取得了较好疗效。它在炎症与免疫方面的作用也日益受到重视。LTRAs可以抑制气道炎症细胞的黏附、聚集和增殖 ;诱导细胞凋亡 ;影响细胞因子和炎症介质的释放 ;降低气道高反应性 ;减少气道黏液分泌 ;抑制气道重塑和抗肺纤维化 ;降低呼出气中的NO含量。另外 ,在其它组织中它也具有一定的抗炎作用。最近发现它在免疫系统的调节中可能也有较大的影响。LTRAs是一类具有多种作用、高效、低毒、安全性好的平喘抗炎药。具有广阔的应用前景。
引用
收藏
页码:40 / 43
页数:4
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