炎症:肿瘤的推进器

被引:42
作者
王一
黎燕
沈倍奋
陈国江
机构
[1] 军事医学科学院基础医学研究所免疫学研究室
基金
北京市自然科学基金;
关键词
炎症; 肿瘤; 炎性细胞因子; 肿瘤治疗;
D O I
10.13220/j.cnki.jipr.2014.01.009
中图分类号
R730.5 [肿瘤治疗学];
学科分类号
100214 [肿瘤学];
摘要
目前,肿瘤是人类疾病的头号死因,尽管其死亡率在过去几十年间一直在下降,但下降幅度仅为10%,与曾经的高死亡率疾病(如鼠疫、天花、流行性感冒和肺结核)相比微不足道。因此,战胜肿瘤还有很长的路要走。大量的研究表明,炎症与肿瘤似乎是一对相生相伴的疾病,炎性微环境因素及其影响日益受到研究者的重视,很可能为攻克肿瘤治疗难题提供全新的思路。本文综述了炎症在肿瘤的产生、发展、转移中的作用以及靶向炎症相关因子治疗肿瘤的研究进展。
引用
收藏
页码:63 / 67+74+4 +74
页数:7
相关论文
共 23 条
[1]
Emerging targets in cancer management: role of the CXCL12/CXCR4 axis.[J].Anna Dubrovska;Polishchuk;Franzi Trautmann;Peitzsch;Monica Cojoc;Telegeev.OncoTargets and Therapy.2013, defa
[2]
The role of chronic prostatic inflammation in the pathogenesis and progression of benign prostatic hyperplasia (BPH) [J].
Gandaglia, Giorgio ;
Briganti, Alberto ;
Gontero, Paolo ;
Mondaini, Nicola ;
Novara, Giacomo ;
Salonia, Andrea ;
Sciarra, Alessandro ;
Montorsi, Francesco .
BJU INTERNATIONAL, 2013, 112 (04) :432-441
[3]
How should we define STAT3 as an oncogene and as a potential target for therapy?.[J].Hélène Sellier;Amélie Rébillard;Catherine Guette;Benjamin Barré;Olivier Coqueret.JAK-STAT.2013, 3
[4]
Biologic Therapy and Surgery for Crohn Disease [J].
Paulson, E. Carter .
CLINICS IN COLON AND RECTAL SURGERY, 2013, 26 (02) :128-133
[5]
Inflammation, Cytokines and Insulin Resistance: A Clinical Perspective [J].
Wieser, Verena ;
Moschen, Alexander R. ;
Tilg, Herbert .
ARCHIVUM IMMUNOLOGIAE ET THERAPIAE EXPERIMENTALIS, 2013, 61 (02) :119-125
[6]
Targeting interleukin-1β in CAPS (cryopyrin-associated periodic) syndromes.[J].Isabelle Koné-Paut;Maryam Piram.Autoimmunity Reviews.2012, 1
[7]
The AID Dilemma.[J].Tasuku Honjo;Maki Kobayashi;Nasim Begum;Ai Kotani;Somayeh Sabouri;Hitoshi Nagaoka.Advances in Cancer Research.2012,
[8]
The JAK2 Inhibitor AZD1480 Potently Blocks Stat3 Signaling and Oncogenesis in Solid Tumors [J].
Hedvat, Michael ;
Huszar, Dennis ;
Herrmann, Andreas ;
Gozgit, Joseph M. ;
Schroeder, Anne ;
Sheehy, Adam ;
Buettner, Ralf ;
Proia, David ;
Kowolik, Claudia M. ;
Xin, Hong ;
Armstrong, Brian ;
Bebernitz, Geraldine ;
Weng, Shaobu ;
Wang, Lin ;
Ye, Minwei ;
McEachern, Kristen ;
Chen, Huawei ;
Morosini, Deborah ;
Bell, Kirsten ;
Alimzhanov, Marat ;
Ioannidis, Stephanos ;
McCoon, Patricia ;
Cao, Zhu A. ;
Yu, Hua ;
Jove, Richard ;
Zinda, Michael .
CANCER CELL, 2009, 16 (06) :487-497
[9]
Stabilization of Snail by NF-κB Is Required for Inflammation-Induced Cell Migration and Invasion [J].
Wu, Yadi ;
Deng, Jiong ;
Rychahou, Piotr G. ;
Qiu, Suimin ;
Evers, B. Mark ;
Zhou, Binhua P. .
CANCER CELL, 2009, 15 (05) :416-428
[10]
Regulation of the IL-23 and IL-12 Balance by Stat3 Signaling in the Tumor Microenvironment [J].
Kortylewski, Marcin ;
Xin, Hong ;
Kujawski, Maciej ;
Lee, Heehyoung ;
Liu, Yong ;
Harris, Timothy ;
Drake, Charles ;
Pardoll, Drew ;
Yu, Hua .
CANCER CELL, 2009, 15 (02) :114-123