Bcl-2基因家族研究进展

被引：93

作者：

任玉伟

宿华威

机构：

[1] 哈尔滨医科大学附属第二临床医院胆道、腹腔镜微创外科

来源：

大连医科大学学报 | 2015年 / 37卷 / 02期

关键词：

Bcl-2; 细胞凋亡; 线粒体; 内质网; 缺血再灌注损伤;

D O I：

暂无

中图分类号：

R346 [];

学科分类号：

摘要：

Bcl-2家族蛋白是细胞凋亡的关键调节分子,线粒体、内质网等在细胞凋亡的过程中扮演着重要的角色,Bcl-2家族蛋白可直接或间接作用于线粒体来发挥它们的相应功能。Bcl-2基因家族在缺血再灌注损伤(IRI)中也有着独特的地位。而且Bcl-2家族的表达和调控对肿瘤细胞凋亡也具有较大的影响,如何调控Bcl-2家族成员的表达和表达后的针对性治疗,成为今后研究的一个方向。本文对Bcl-2目前的研究进展作一综述。

引用

页码：202 / 205

页数：4

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