细胞信号转导的复杂网络分析

被引:3
作者
潘义
冯子男
刁元波
向杰
文志宁
李梦龙
机构
[1] 四川大学化学学院
关键词
细胞信号转导; 复杂系统; 无尺度网络; 生物信息学;
D O I
10.16866/j.com.app.chem2007.01.016
中图分类号
Q26 [细胞生物化学];
学科分类号
071009 ; 090102 ;
摘要
基于KEGG数据库,构建了一个节点数N=933,连接数L=6825的细胞信号转导网络.该网络为具幂律形式的度分布、遵循BA模型的无尺度网络;其中γ指数为1.7,平均路径长度5.63。通过广度优先搜索算法构建本网络的距离矩阵,并进行聚类分析,实现了对该信号网络的可视化处理和拓扑结构分析。结果表明,此细胞信号转导网络可以较好地描述细胞内蛋白质之间的相互作用关系,其基本属性与先验知识有较好的一致性。
引用
收藏
页码:56 / 60
页数:5
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