Nrf2/HO-1通路在氧化应激和炎性反应中的作用

被引：21

作者：

于馨雅

申元英

郭乐

机构：

[1] 大理大学基础医学院医学微生物学与免疫学教研室

来源：

医学研究杂志 | 2023年 / 52卷 / 07期

关键词：

核转录因子红系2相关因子2/血红素加氧酶-1; 氧化应激; 炎性反应;

D O I：

暂无

中图分类号：

R364.5 [炎症];

学科分类号：

100103 [病原生物学];

摘要：

氧化应激是指体内氧化与抗氧化作用失衡，倾向于氧化，导致中性粒细胞炎性浸润、蛋白酶分泌增加、产生高活性分子，如活性氧自由基（reactive oxygen species, ROS）和活性氮自由基（reactive nitrogen species, RNS）以及大量氧化中间产物，如白三烯、血栓素A2等促炎介质，从而引起细胞凋亡和炎性反应。近年来研究表明，核转录因子红系2相关因子2/血红素加氧酶-1（nuclear factor erythroid-2-related factor 2/heme oxygenase 1, Nrf2/HO-1）通路可以通过抗炎、抗氧化等作用抵抗氧化应激损伤。因此，有效调控Nrf2/HO-1通路可成为治疗氧化应激性疾病和炎性疾病的重要靶点。

引用

页码：19 / 22

页数：4

共 25 条

[1]

Honokiol alleviates LPS-induced acute lung injury by inhibiting NLRP3 inflammasome-mediated pyroptosis via Nrf2 activation in vitro and in vivo [J].

Liu, Yuhan ;

Zhou, Jiabin ;

Luo, Yingying ;

Li, Jinxiao ;

Shang, Luorui ;

Zhou, Fangyuan ;

Yang, Shenglan .

CHINESE MEDICINE, 2021, 16 (01)

[2]

SERCA2a.[J].Wu Tengfei;Yao Hui;Zhang Binghua;Zhou Shenglai;Hou Ping;Chen Keyan.Oxidative Medicine and Cellular Longevity.2021,

[3]

Synergistic Protection by Isoquercitrin and Quercetin against Glutamate-Induced Oxidative Cell Death in HT22 Cells via Activating Nrf2 and HO-1 Signaling Pathway: Neuroprotective Principles and Mechanisms of Dendropanax morbifera Leaves [J].

Park, Hye-Jin ;

Kim, Ha-Neul ;

Kim, Chul Young ;

Seo, Min-Duk ;

Baek, Seung-Hoon .

ANTIOXIDANTS, 2021, 10 (04)

[4]

Activation of autophagy and suppression of apoptosis by dapagliflozin attenuates experimental inflammatory bowel disease in rats: Targeting AMPK/mTOR; HMGB1/RAGE and Nrf2/HO-1 pathways.[J].Arab Hany H.;Al-Shorbagy Muhammad Y.;Saad Muhammed A..Chemico-Biological Interactions.2021,

[5]

Circadian clock gene BMAL1 reduces urinary calcium oxalate stones formation by regulating NRF2/HO-1 pathway [J].

Wang, Jiahao ;

Bai, Yunjin ;

Yin, Shan ;

Cui, Jianwei ;

Zhang, Yu ;

Wang, Xiaoming ;

Zhang, Facai ;

Li, Hong ;

Tang, Yin ;

Wang, Jia .

LIFE SCIENCES, 2021, 265

[6]

Activation of autophagy by sitagliptin attenuates cadmium-induced testicular impairment in rats: Targeting AMPK/mTOR and Nrf2/HO-1 pathways.[J].Arab Hany H.;Gad Amany M.;Reda Enji;Yahia Rania;Eid Ahmed H..Life Sciences.2021, prepublish

[7]

Ferroptosis mediated DSS-induced ulcerative colitis associated with Nrf2/HO-1 signaling pathway.[J].Yeru Chen;Piao Zhang;Wenru Chen;Gang Chen.Immunology Letters.2020,

[8]

Eldecalcitol Inhibits LPS-Induced NLRP3 Inflammasome-Dependent Pyroptosis in Human Gingival Fibroblasts by Activating the Nrf2/HO-1 Signaling Pathway..[J].Huang Cancan;Zhang Chaotao;Yang Panpan;Chao Rui;Yue Ziqi;Li Congshan;Guo Jie;Li Minqi.Drug design; development and therapy.2020,

[9]

Paeoniflorin Prevents Intestinal Barrier Disruption and Inhibits Lipopolysaccharide (LPS)-Induced Inflammation in Caco-2 Cell Monolayers [J].