骨关节炎软骨组织退变分子机制研究进展

被引：6

作者：

鲜晓梅

机构：

[1] 哈尔滨商业大学药学院

来源：

黑龙江医药 | 2014年 / 27卷 / 02期

关键词：

骨关节炎; 软骨细胞; 生长因子; MMP13;

D O I：

10.14035/j.cnki.hljyy.2014.02.093

中图分类号：

R684.3 [关节炎];

学科分类号：

100220 [骨科学];

摘要：

骨性关节炎(OA)是一种非常普遍的疾病,可分为原发性和继发性。继发性OA有明确的致病原因,如创伤、炎性关节病、先天性或发育性骨关节病、代谢性或内分泌性疾病等;原发性OA病因及发病机制尚不十分明确,可能与年龄增长、过度使用、损伤、肥胖、遗传等多种因素密切相关。然而,OA分子作用机制是复杂的,目前尚没有有效的治疗。OA的启动和发展是一个复杂的过程,在分子水平上,可能包括许多细胞类型,信号通路和细胞外基质的变化。本文的研究重点在于OA产生的分子机制与最新研究结果的相关性。

引用

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页码：272 / 275

页数：4

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共 9 条

[1]

上海市中心城区老年人膝关节骨关节炎流行病学调查 [J].

李立强 .

黑龙江医药, 2007, (04) :347-348

[2]

Osteoarthritis year 2010 in review: pathomechanisms [J].

van den Berg, W. B. .

OSTEOARTHRITIS AND CARTILAGE, 2011, 19 (04) :338-341

[3]

Osteoarthritis: an update with relevance for clinical practice [J].

Bijlsma, Johannes W. J. ;

Berenbaum, Francis ;

Lafeber, Foris P. J. G. .

LANCET, 2011, 377 (9783) :2115-2126

[4]

Genetic Variation in the SMAD3 Gene Is Associated With Hip and Knee Osteoarthritis [J].

Valdes, Ana M. ;

Spector, Tim D. ;

Tamm, Agu ;

Kisand, Kalle ;

Doherty, Sally A. ;

Dennison, Elaine M. ;

Mangino, Massimo ;

Tamm, Ann ;

Kerna, Irina ;

Hart, Deborah J. ;

wheeler, Margaret ;

Cooper, Cyrus ;

Lories, Rik J. ;

Arden, Nigel K. ;

Doherty, Michael .

ARTHRITIS AND RHEUMATISM, 2010, 62 (08) :2347-2352

[5]

Matrix metalloproteinases, a disintegrin and metalloproteinases, and a disintegrin and metalloproteinases with thrombospondin motifs in non-neoplastic diseases [J].

Shiomi, Takayuki ;

Lemaitre, Vincent ;

D'Armiento, Jeanine ;

Okada, Yasunori .

PATHOLOGY INTERNATIONAL, 2010, 60 (07) :477-496

[6]

Induction of an Osteoarthritis-like Phenotype and Degradation of Phosphorylated Smad3 by Smurf2 in Transgenic Mice [J].

Wu, Qiuqian ;

Kim, Kyung-Ok ;

Sampson, Erik R. ;

Chen, Di ;

Awad, Hani ;

O'Brien, Todd ;

Puzas, J. Edward ;

Drissi, Hicham ;

Schwarz, Edward M. ;

O'Keefe, Regis J. ;

Zuscik, Michael J. ;

Rosier, Randy N. .

ARTHRITIS AND RHEUMATISM, 2008, 58 (10) :3132-3144

[7]

TGF-β and osteoarthritis [J].

Davidson, E. N. Blaney ;

van der Kraan, P. M. ;

van den Berg, W. B. .

OSTEOARTHRITIS AND CARTILAGE, 2007, 15 (06) :597-604

[8]

Association between the abnormal expression of matrix-degrading enzymes by human osteoarthritic chondrocytes and demethylation of specific CpG sites in the promoter regions [J].

Roach, HI ;

Yamada, N ;

Cheung, KSC ;

Tilley, S ;

Clarke, NMP ;

Oreffo, ROC ;

Kokubun, S ;

Bronner, F .

ARTHRITIS AND RHEUMATISM, 2005, 52 (10) :3110-3124

[9]

Transcriptional regulation of collagenase (MMP-1, MMP-13) genes in arthritis: integration of complex signaling pathways for the recruitment of gene-specific transcription factors [J].

Vincenti, MP ;

Brinckerhoff, CE .

ARTHRITIS RESEARCH, 2002, 4 (03) :157-164