Akt信号通路在胰岛β细胞功能中的研究进展

被引：18

作者：

李晓瑾

母义明

机构：

[1] 解放军总医院内分泌科

来源：

医学综述 | 2012年 / 18卷 / 08期

关键词：

胰岛β细胞; Akt; 增殖; 凋亡; 胰岛素;

D O I：

暂无

中图分类号：

R587.1 [糖尿病];

学科分类号：

100201 [内科学];

摘要：

PI3K是调节Akt活性的重要分子。生长因子通过Akt通路将信号传递至细胞内,对细胞的多种生物功能起调节作用。Akt共有3种亚型,它们均表达于胰岛β细胞。在胰岛β细胞中Akt以依赖于PI3K的方式被激活。大量研究发现,Akt信号通路在调节胰岛β细胞增殖、凋亡、胰岛素分泌、再生中起着重要的作用,现对Akt信号通路在胰岛β细胞功能中研究的新进展予以综述。

引用

页码：1121 / 1124

页数：4

共 9 条

[1]

Conditional ablation of Gsk-3β in islet beta cells results in expanded mass and resistance to fat feeding-induced diabetes in mice [J].

Liu, Y. ;

Tanabe, K. ;

Baronnier, D. ;

Patel, S. ;

Woodgett, J. ;

Cras-Meneur, C. ;

Permutt, M. A. .

DIABETOLOGIA, 2010, 53 (12) :2600-2610

[2]

High glucose induces suppression of insulin signalling and apoptosis via upregulation of endogenous IL-1β and suppressor of cytokine signalling-1 in mouse pancreatic beta cells [J].

Venieratos, Panagiotis D. ;

Drossopoulou, Garyfalia I. ;

Kapodistria, Katerina D. ;

Tsilibary, Effie C. ;

Kitsiou, Paraskevi V. .

CELLULAR SIGNALLING, 2010, 22 (05) :791-800

[3]

Activation of the AMP-activated protein kinase enhances glucose-stimulated insulin secretion in mouse β-cells [J].

Duefer, Martina ;

Noack, Katja ;

Krippeit-Drews, Peter ;

Drews, Gisela .

ISLETS, 2010, 2 (03) :156-163

[4]

Effect of forkhead box O1 (FOXO1) on beta cell development in the human fetal pancreas [J].

Al-Masri, M. ;

Krishnamurthy, M. ;

Li, J. ;

Fellows, G. F. ;

Dong, H. H. ;

Goodyer, C. G. ;

Wang, R. .

DIABETOLOGIA, 2010, 53 (04) :699-711

[5]

Insulin receptor signaling for the proliferation of pancreatic β-cells Involvement of Ca2+ second messengers, IP3, NAADP and cADPR [J].

Shawl, Asif Iqbal ;

Park, Kwang-Hyun ;

Kim, Uh-Hyun .

ISLETS, 2009, 1 (03) :216-223

[6]

Adenovirus Infection Activates Akt1 and Induces Cell Proliferation in Pancreatic Islets1.[J].Mert Icyuz;Stacie M.J. Bryant;Henry K. Fortinberry;Kfir Molakandov;Gene P. Siegal;Juan L. Contreras;Hongju Wu.Transplantation.2009, 6

[7]

Role of oxidative stress; endoplasmic reticulum stress; and c-Jun N-terminal kinase in pancreatic β-cell dysfunction and insulin resistance.[J].Hideaki Kaneto;Yoshihisa Nakatani;Dan Kawamori;Takeshi Miyatsuka;Taka-aki Matsuoka;Munehide Matsuhisa;Yoshimitsu Yamasaki.International Journal of Biochemistry and Cell Biology.2006, 5

[8]

On the role of IRS2 in the regulation of functional β-cell mass.[J].Markus Niessen.Archives of Physiology and Biochemistry.2006, 2

[9]

PHLPP: A phosphatase that directly dephosphorylates akt, promotes apoptosis, and suppresses tumor growth [J].

Gao, TY ;

Furnari, F ;

Newton, AC .

MOLECULAR CELL, 2005, 18 (01) :13-24

← 1 →