IL-3,IL-6和IL-4单独或联合G-CSF及GM-CSF对小鼠异基因骨髓移植后造血重建的影响

被引:2
作者
朱康儿
KerryAtkinson
机构
[1] 浙江医科大学附属第一医院!杭州
[2] 澳大利亚悉尼StVincent医院
关键词
细胞因子; 骨髓移植; 异基因; 造血重建;
D O I
暂无
中图分类号
R457.7 [骨髓移植];
学科分类号
100215 ;
摘要
我们检测了IL-3,IL-6和IL-4单独和联合G-CSF和GM-CSF对小鼠异基因骨髓移植后造血重建的影响.IL-3+GM-CSF是增加移植后6d中性粒细胞绝对计数最有效的联合,显示显著的协同作用.当单独给予时,IL-6和G-CSF分别显著增加移植后6d血小板计数,而在联合给予中,只有IL-3+G-CSF显著增加移植后6d的血小板计数.IL-4对移植后7d中性粒细胞恢复有显著的抑制作用.对由IL-3和G-CSF加速的中性粒细胞恢复亦有显著的抑制作用.
引用
收藏
页码:135 / 138
页数:4
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