点燃鼠痫性发作对神经元凋亡的影响

被引:11
作者
史东葵
晏勇
王学峰
机构
[1] 重庆医科大学附属第一医院神经内科
关键词
点燃鼠; 痫性发作; 神经元凋亡;
D O I
暂无
中图分类号
R742.1 [癫痫];
学科分类号
1002 ;
摘要
目的 观察点燃大鼠痫性发作对神经元凋亡的影响。方法 用 IS- II型智能刺激仪点燃大鼠致痫性反复发作 ,并用原位末端标记染色法显示点燃后不同时期的凋亡细胞。结果 发现痫性发作后海马、杏仁核、大脑皮质、丘脑、小脑神经元凋亡明显增多。其海马 CA3、CA1 区凋亡细胞在 2 4小时最多 ,且持续 3周以上。结论 痫性发作可使痫灶局部和远隔痫灶的神经元凋亡 ,此可能与顽固性癫痫的成因有关。
引用
收藏
页码:76 / 78
页数:3
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