特发性震颤的研究进展

被引：16

作者：

赵彦胤

丁正同

机构：

[1] 复旦大学附属华山医院神经内科

来源：

中国临床神经科学 | 2009年 / 17卷 / 03期

关键词：

特发性震颤; 病因; 临床表现; 诊断; 治疗;

D O I：

暂无

中图分类号：

R741 [神经病学];

学科分类号：

1002 ;

摘要：

特发性震颤(ET)的病因可能包括环境和遗传因素。血中哈尔碱和铅浓度的增高可能和ET发病有关。遗传具有异质性,目前已经发现有3个基因位点可能与其发病有关,GABA转运体1型(GABA transporter subtype 1,GAT1)可能为另一个候选基因。除震颤外,ET患者还可有小脑体征、执行功能受损和痴呆等表现。目前有一些新的辅助检查手段帮助鉴别ET,尤其是与早期帕金森病震颤相鉴别。一些新的药物也被证实有效。

引用

页码：300 / 304

页数：5

共 15 条

[1] Long-term EMG recordings differentiate between parkinsonian and essential tremor [J].

Breit, S. ;

Spieker, S. ;

Schulz, J. B. ;

Gasser, T. .

JOURNAL OF NEUROLOGY, 2008, 255 (01) :103-111

[2]

Dietary Epidemiology of Essential Tremor: Meat Consumption and Meat Cooking Practices[J] . Louis,Elan D,Keating,Garrett A,Bogen,Kenneth T,Rios,Eileen,Pellegrino,Kathryn M,Factor-litvak,Pam.Neuroepidemiology . 2008 (3)

[3]

Population‐based case–control study of cigarette smoking and essential tremor[J] . JuliánBenito‐León,Elan D.Louis,FélixBermejo‐Pareja.Mov. Disord. . 2008 (2)

[4] A population-based study of mortality in essential tremor [J].

Louis, Elan D. ;

Benito-Leon, Julian ;

Ottman, Ruth ;

Bermejo-Pareja, Felix .

NEUROLOGY, 2007, 69 (21) :1982-1989

[5] Population-based case-control study of cognitive function in essential tremor [J].

Benito-León, J ;

Louis, ED ;

Bermejo-Pareja, F .

NEUROLOGY, 2006, 66 (01) :69-74

[6] Influence of alcohol on gait in patients with essential tremor [J].

Klebe, S ;

Stolze, H ;

Grensing, K ;

Volkmann, J ;

Wenzelburger, R ;

Deuschl, G .

NEUROLOGY, 2005, 65 (01) :96-101

[7] A variant in the HS1-BP3 gene is associated with familial essential tremor [J].

Higgins, JJ ;

Lombardi, RQ ;

Pucilowska, J ;

Jankovic, J ;

Tan, EK ;

Rooney, JP .

NEUROLOGY, 2005, 64 (03) :417-421

[8]

Practice Parameter: Therapies for essential tremor: Report of the Quality Standards Subcommittee of the American Academy of Neurology[J] . T A. Zesiewicz,R Elble,E D. Louis,R A. Hauser,K L. Sullivan,R B. Dewey,W G. Ondo,G S. Gronseth,W J. Weiner.Neurology . 2005 (12)

[9] The effect of levetiracetam on essential tremor [J].

Bushara, KO ;

Malik, T ;

Exconde, RE .

NEUROLOGY, 2005, 64 (06) :1078-1080

[10]

The gait disorder of advanced essential tremor[J] . Henning Stolze,Gesche Petersen,Jan Raethjen,Roland Wenzelburger.Brain . 2001

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