血脑屏障破坏与脑水肿发生研究进展

被引：16

作者：

侯景明

黎海涛

机构：

[1] 第三军医大学第一附属医院放射科

来源：

国际神经病学神经外科学杂志 | 2010年 / 37卷 / 03期

关键词：

血脑屏障; 脑水肿; 紧密连接蛋白; 水通道蛋白; 基质金属蛋白酶; 血管内皮生长因子;

D O I：

10.16636/j.cnki.jinn.2010.03.010

中图分类号：

R741 [神经病学];

学科分类号：

1002 ;

摘要：

血脑屏障是机体维持中枢神经系统内环境稳定的结构基础,在脑水肿的形成过程中起着重要作用。近年来,发现了一些因子参与了血脑屏障功能的破坏而导致脑水肿的形成,这些因子主要包括:水通道蛋白(AQP)、基质金属蛋白酶(MMP)、血管内皮生长因子(VEGF)和血管生成素等。本文通过对这些因子在血脑屏障破坏过程中所起的作用进行综述,进一步阐述血脑屏障破坏导致脑水肿发生的分子机制。结合目前的研究,对脑水肿的防治进行展望。

引用

页码：260 / 263

页数：4

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