NLRP3炎症小体与溃疡性结肠炎的研究进展

被引：23

作者：

史济华

许乐

机构：

[1] 北京医院消化内科

来源：

基础医学与临床 | 2015年 / 35卷 / 07期

关键词：

溃疡性结肠炎; NLRP3炎症小体;

D O I：

10.16352/j.issn.1001-6325.2015.07.032

中图分类号：

R574.62 [结肠疾病];

学科分类号：

100201 [内科学];

摘要：

溃疡性结肠炎是肠道慢性炎性反应性疾病,遗传易感性、肠道菌群和黏膜免疫功能失调在溃疡性结肠炎的发生发展过程中起重要作用。目前研究显示NLRP3基因与溃疡性结肠炎的易感性相关,NLRP3炎症小体可维持肠道内环境稳定,对实验性结肠炎具有保护作用,其功能缺陷可能导致对溃疡性结肠炎易感。NLRP3炎症小体有可能成为溃疡性结肠炎治疗的新靶点。

引用

页码：989 / 992

页数：4

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