热休克蛋白70-2和肿瘤坏死因子α基因多态性与儿童过敏性紫癜相关性研究

被引：11

作者：

管皖珍

杨小凤

袁杨刚

苏敏

丁桂霞

黄松明

张爱华

机构：

[1] 南京医科大学附属南京儿童医院肾内科

来源：

中国循证儿科杂志 | 2013年 / 8卷 / 03期

关键词：

热休克蛋白70-2; 肿瘤坏死因子α; 基因多态性; 过敏性紫癜;

D O I：

暂无

中图分类号：

R725.5 [小儿血液及淋巴系疾病];

学科分类号：

100201 [内科学];

摘要：

目的观察热休克蛋白70-2(HSP70-2)和TNF-α基因多态性与儿童过敏性紫癜(HSP)的相关性。方法纳入2008年9月至2009年5月在南京儿童医院诊断为HSP的患儿为HSP组,健康查体儿童为对照组。采用PCR-RFLP法检测两组HSP70-2基因1267A/G和TNF-α基因-380G/A多态性,并分析其与HSP和肾损害的相关性。结果 HSP组纳入205例,对照组纳入53名。①HSP组和对照组HSP70-2基因1267位点GG基因型频率分别为22.9%和9.4%,差异有统计学意义(χ2=4.764,P<0.05);非肾损害亚组和肾损害亚组AA、AG、GG基因型频率差异无统计学意义。②HSP组和对照组TNF-α基因-308位点AA基因型频率分别为8.3%和1.9%,差异有统计学意义(χ2=6.447,P<0.05);A等位基因频率HSP组高于对照组(24.4%vs12.3%,χ2=7.241,P<0.05);非肾损害亚组和肾损害亚组GG、GA、AA基因型和A等位基因频率差异均无统计学意义。结论 HSP70-2基因1267位点GG基因型、TNF-α基因-308位点AA基因型可能是HSP发病的遗传学易感因素,但与肾损害发展可能无明显相关性。

引用

页码：224 / 227

页数：4

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