NF-κB在类风湿性关节炎中的作用及调控机制

被引:18
作者
王晨
程艳杰
机构
[1] 大连医科大学附属第一医院检验科
关键词
NF-κB; 类风湿性关节炎; 促炎作用;
D O I
暂无
中图分类号
R593.22 [类风湿性关节炎];
学科分类号
100201 [内科学];
摘要
<正>类风湿性关节炎(RA)是1种慢性、系统性自身免疫性疾病,可累及人体许多组织与器官,对关节的破坏尤为严重。主要病理特征为炎性细胞浸润、滑膜组织增生、血管生成、血管翳形成、软骨的破坏及骨的侵蚀。目前认为炎性反应介质的持续作用是RA病变加重的主要原因。NF-κB是1种影响广泛的转录因子,能促进多种基因转录和表达,与炎性反应、免疫应答
引用
收藏
页码:2600 / 2603
页数:4
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