电子垃圾拆解区居民血清中甲状腺激素和性激素水平研究

被引:6
作者
居颖 [1 ]
陈兰 [1 ]
苏萍 [2 ]
石吉彬 [1 ]
江琦 [1 ]
袁晶 [1 ]
邬堂春 [1 ]
陈学敏 [1 ]
机构
[1] 华中科技大学同济医学院公共卫生学院劳动卫生与环境卫生学系环境与健康教育部重点实验室
[2] 华中科技大学同济医学院计划生育研究所
基金
国家自然科学基金重大项目;
关键词
环境污染物; 电子垃圾; 甲状腺激素; 性激素;
D O I
10.16241/j.cnki.1001-5914.2008.06.021
中图分类号
R181.3 [流行病学各论];
学科分类号
摘要
目的探讨电子垃圾拆解区居民血清中甲状腺激素和性激素水平的变化。方法于2005年8—12月在我国南方某有10余年历史的电子垃圾拆解区(暴露组)及距该地区约50km无明显工业污染的农业区(对照组)分别随机选取当地居民58名和80名。用免疫化学发光分析(immunochemiluminometric assay,ICMA)法检测两组居民血清甲状腺激素[包括游离三碘甲状腺原氨酸(free triiodothyronine,FT3)、游离四碘甲状腺原氨酸(free thyroxine,FT4)、促甲状腺激素(thyroidstimulating hormone,TSH)]和性激素[包括雌二醇(estradiol,E2)、孕酮(progesterone,Pro)、睾酮(testerone,T)]水平,并分析其影响因素。结果暴露组血清中FT4水平低于对照组(P<0.05);但TSH水平高于对照组(P<0.05)。男性居民中,暴露组血清中E2和T均低于对照组(P<0.05);在女性中,暴露组血清中Pro水平高于对照组(P<0.05)。电子垃圾拆解职业暴露史是TSH水平升高的危险因素(OR=3.88,P<0.01);性别(OR=0.39,P<0.05)和电子设备拥有情况(OR=0.33,P<0.05)是FT3水平降低的保护因素。结论电子垃圾处理环境暴露可能对当地居民血清中甲状腺激素和性激素水平有影响。
引用
收藏
页码:499 / 503
页数:5
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