硫酸/盐酸氨基葡萄糖治疗骨关节炎的Meta分析

被引：16

作者：

何训

郭佳奕

吕世文

机构：

[1] 金华市中心医院药剂科

来源：

中国医院统计 | 2019年 / 26卷 / 01期

关键词：

氨基葡萄糖; 骨关节炎; 硫酸/盐酸;

D O I：

暂无

中图分类号：

R684.3 [关节炎];

学科分类号：

100220 [骨科学];

摘要：

目的评价硫酸/盐酸氨基葡萄糖治疗骨关节炎的有效性及安全性。方法系统检索Medline数据库、Embase数据库和Cochrane图书馆硫酸/盐酸氨基葡萄糖治疗骨关节炎的随机对照研究,采用Cochrane质量评价标准进行定量化质量评估,采用Rev Man 5.3进行系统统计分析。结果共纳入15项随机对照研究,Meta分析研究结果发现,氨基葡萄糖可减轻骨关节炎疼痛程度(ES=-0.37,P<0.001)。进一步结果显示,与安慰剂相比,硫酸氨基葡萄糖可减轻骨关节炎疼痛,且差别具有统计学意义(ES=-0.54,P<0.001);而盐酸氨基葡萄糖亦可减轻骨关节炎疼痛,但差别无统计学意义(ES=-0.04,P=0.22)。硫酸/盐酸氨基葡萄糖不良反应发生率均较低。结论氨基葡萄糖可减轻骨关节炎疼痛,且安全性较好。

引用

页码：5 / 9

页数：5

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