活化型肝星状细胞清除机制及其相关抗肝纤维化策略

被引：5

作者：

李晶

殷正丰

机构：

[1] 第二军医大学东方肝胆外科医院分子肿瘤实验室

来源：

第二军医大学学报 | 2010年 / 31卷 / 09期

关键词：

肝纤维化; 肝星状细胞; 表型; 细胞凋亡;

D O I：

暂无

中图分类号：

R575.2 [肝硬变];

学科分类号：

100201 [内科学];

摘要：

已知肝星状细胞(hepatic stellate cells,HSCs)活化是肝纤维化的核心环节。越来越多的基础和临床研究证实,肝纤维化可以逆转。而肝纤维化消退的主要表现之一是活化型HSCs数量不断减少。因此,如何清除活化型HSCs并使之成为抗肝纤维化治疗新策略正逐渐受到关注。现有两种可能机制用于解释活化型HSCs的清除现象,即活化型HSCs的表型逆转和凋亡。本文旨在对基于活化型HSCs清除机制的抗肝纤维化策略进展做一综述。

引用

页码：1017 / 1019

页数：3

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