双膦酸盐在骨质疏松症的应用:回眸中国20年

被引：21

作者：

夏维波

机构：

[1] 中国医学科学院北京协和医学院北京协和医院内分泌科国家卫生健康委员会内分泌重点实验室

来源：

中华骨质疏松和骨矿盐疾病杂志 | 2018年 / 11卷 / 06期

关键词：

骨质疏松症; 双膦酸盐; 骨折; 中国;

D O I：

暂无

中图分类号：

R580 [];

学科分类号：

摘要：

双膦酸盐是目前治疗骨质疏松的有效药物之一,能特异地与骨质中的羟磷灰石结合,抑制破骨细胞活性,从而抑制骨吸收。大量临床研究显示双膦酸盐能有效降低绝经后妇女骨质疏松的椎体、非椎体和髋部骨折风险。本文复习双膦酸盐在中国人群防治骨质疏松症的循证医学证据,并探讨其临床应用的特殊性,包括疗效评估与骨折风险预测、骨折期间用药时机、长程治疗对策、联合治疗与序贯治疗的探索以及提高依从性的认识,旨在为双膦酸盐在骨质疏松症规范使用提供参照。

引用

页码：521 / 531

页数：11

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