局部肾素-血管紧张素-醛固酮系统与糖尿病肾病的治疗

被引:8
作者
徐茜
汤正义
杨洋
田秀丽
黄佳佳
王卫庆
宁光
机构
[1] 上海交通大学医学院附属瑞金医院内分泌科
[2] 上海市内分泌代谢病临床中心
[3] 上海市内分泌代谢病研究所
关键词
糖尿病肾病; 局部; 肾素-血管紧张素-醛固酮系统; 血管紧张素Ⅱ; 醛固酮; 炎症因子;
D O I
暂无
中图分类号
R587.2 [糖尿病性昏迷及其他并发症]; R692 [肾疾病];
学科分类号
1002 ; 100201 ; 100210 ;
摘要
循环中肾素-血管紧张素-醛固酮系统(RAAS)成分由分布于全身的组织细胞合成与分泌。糖尿病时,肾脏局部肾素、血管紧张素(Ang)Ⅱ、醛固酮等活性增加,它们作用于血管或通过激活炎症因子等途径,导致肾血管病变及肾纤维化。动物试验与临床研究表明,抑制RAAS可延缓糖尿病肾病进程。
引用
收藏
页码:647 / 650
页数:4
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