HIV Vpr蛋白诱导细胞凋亡研究进展

被引:2
作者
魏强
王健伟
李凡
洪涛
机构
[1] 吉林大学基础医学院
[2] 中国疾病预防控制中心病毒病预防控制所
[3] 中国疾病预防控制中心病毒病预防控制所 吉林
[4] 北京
[5] 吉林
关键词
HIV Vpr; 细胞凋亡; 线粒体;
D O I
10.13523/j.cb.20030902
中图分类号
R346 [];
学科分类号
1001 ;
摘要
Vpr蛋白是HIV的一个辅助蛋白 ,可以诱导多种细胞的凋亡。目前的研究表明Vpr蛋白引起细胞凋亡主要是通过线粒体途径实现的。Vpr蛋白通过直接而且特异地与结合在PTPC中的ANT相互作用 ,改变线粒体膜通透性 ,导致凋亡诱导因子 (AIF)和细胞色素C的释放 ,激活Caspase、DNases等的级联反应 ,引起核染色质的固缩 ,最终引起细胞凋亡。
引用
收藏
页码:6 / 10
页数:5
相关论文
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