丹参对鼠脑缺血再灌注后白细胞介素-1β转化酶表达的影响

被引：18

作者：

张金涛

吴卫平

刘洁晓

张凤英

机构：

[1] 解放军第医院神经内科!山东泰安

[2] 解放军总医院神经内科!北京

来源：

中华老年心脑血管病杂志 | 2000年 / 02期

关键词：

丹参; 脑缺血; 白细胞介素1; 基因表达;

D O I：

暂无

中图分类号：

R285 [中药药理学];

学科分类号：

摘要：

研究丹参在脑缺血再灌注后对白细胞介素 1β转化酶 (ICE)表达的影响及其神经保护作用。方法　利用沙土鼠前脑缺血再灌注模型 ,应用RT PCR结合免疫组化的方法进行研究。结果　在脑缺血再灌注后 1～ 4d ,皮层及海马可见ICEmRNA表达。免疫组化结果显示脑缺血再灌注后脑组织ICE阳性细胞数显著增多 ,而丹参组ICE表达显著低于缺血对照组 ,但仍显著高于假手术组 (P <0 .0 1) ;丹参预防性干预组与丹参治疗性干预组相比 ,差异也有显著性意义 (P <0 .0 1)。结论　丹参可能通过调节ICE ,进而发挥治疗脑缺血的作用。

引用

页码：124 / 127

页数：4

共 10 条

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