HO-1抗衰老作用研究进展

被引：7

作者：

汤珊珊

张治芬

刘文华

张红艳

邓妙

机构：

[1] 南京医科大学附属杭州医院妇产科

来源：

浙江医学 | 2016年 / 38卷 / 01期

关键词：

D O I：

暂无

中图分类号：

R965 [实验药理学];

学科分类号：

100706 [药理学];

摘要：

<正>血红素加氧酶（hemeoxygenase,HO）属于微粒体酶,在血红素代谢过程中将血红素分解为胆绿素、铁(Fe2+)和一氧化碳（CO）[1]。迄今为止发现的HO有3种不同的亚型,分别为HO-1、HO-2、HO-3。HO-1是分子量为32kDa的微粒体蛋白,主要分布在血细胞代谢活跃的组织器官,如脾脏、肝脏、骨髓中,其他组织中HO-1表达量很低[2]。体内外多种因素可以促进HO-1的表达,如细

引用

页码：70 / 72

页数：3

共 16 条

[1]

Fibroblast growth factor 10 protects neuron against oxygen–glucose deprivation injury through inducing heme oxygenase-1.[J].Yong-Hua Li;Li-Ye Yang;Wei Chen;Ying-Ke Li;Hong-Bin Yuan.Biochemical and Biophysical Research Communications.2014,

[2]

Critical Neuroprotective Roles of Heme Oxygenase-1 Induction Against Axonal Injury-Induced Retinal Ganglion Cell Death [J].

Himori, Noriko ;

Maruyama, Kazuichi ;

Yamamoto, Kotaro ;

Yasuda, Masayuki ;

Ryu, Morin ;

Omodaka, Kazuko ;

Shiga, Yukihiro ;

Tanaka, Yuji ;

Nakazawa, Toru .

JOURNAL OF NEUROSCIENCE RESEARCH, 2014, 92 (09) :1134-1142

[3]

Danhong Injection Attenuates Ischemia/Reperfusion-Induced Brain Damage Which is Associating with Nrf2 Levels In Vivo and In Vitro [J].

Guo, Hong ;

Li, Mei-jiao ;

Liu, Qing-qing ;

Guo, Li-li ;

Ma, Meng-meng ;

Wang, Shao-xia ;

Yu, Bin ;

Hu, Li-Min .

NEUROCHEMICAL RESEARCH, 2014, 39 (09) :1817-1824

[4]

Andrographolide inhibits TNFα-induced ICAM-1 expression via suppression of NADPH oxidase activation and induction of HO-1 and GCLM expression through the PI3K/Akt/Nrf2 and PI3K/Akt/AP-1 pathways in human endothelial cells.[J].Chia-Yang Lu;Ya-Chen Yang;Chien-Chun Li;Kai-Li Liu;Chong-Kuei Lii;Haw-Wen Chen.Biochemical Pharmacology.2014, 1

[5]

HO-1 attenuates hippocampal neurons injury via the activation of BDNF–TrkB–PI3K/Akt signaling pathway in stroke.[J].Dashi Qi;Changjie Ouyang;Yulan Wang;Shichun Zhang;Xijuan Ma;YuanJian Song;HongLi Yu;Jiali Tang;Wei Fu;Lei Sheng;Lihua Yang;Mei Wang;Weihao Zhang;Lei Miao;Tengteng Li;Xiaojing Huang;Hongyan Dong.Brain Research.2014,

[6]

Attenuation of Aβ 25–35 -induced parallel autophagic and apoptotic cell death by gypenoside XVII through the estrogen receptor-dependent activation of Nrf2/ARE pathways.[J].Xiangbao Meng;Min Wang;Guibo Sun;Jingxue Ye;Yanhui Zhou;Xi Dong;Tingting Wang;Shan Lu;Xiaobo Sun.Toxicology and Applied Pharmacology.2014, 1

[7]

Immune Effector Mechanisms Implicated in Atherosclerosis: From Mice to Humans [J].

Libby, Peter ;

Lichtman, Andrew H. ;

Hansson, Goran K. .

IMMUNITY, 2013, 38 (06) :1092-1104

[8]

Proinflammatory Responses of Heme in Alveolar Macrophages: Repercussion in Lung Hemorrhagic Episodes.[J].Rafael L. Sim?es;Maria Augusta Arruda;Cláudio Canetti;Carlos H. Serezani;Iolanda M. Fierro;Christina Barja-Fidalgo;Muzamil Ahmad.Mediators of Inflammation.2013,

[9]

Heme oxygenase-1 induction protects against hypertension associated with diabetes: effect on exaggerated vascular contractility [J].