Th17细胞及相关细胞因子在老年结肠癌患者中的表达

被引：4

作者：

张静

机构：

[1] 武警浙江总队嘉兴医院普外三科

来源：

中国老年学杂志 | 2016年 / 36卷 / 09期

关键词：

结肠癌; Th17细胞; 白细胞介素-6; 白细胞介素-17A;

D O I：

暂无

中图分类号：

R735.35 [];

学科分类号：

摘要：

目的探讨外周血Th17细胞和血清白细胞介素(IL)-6和IL-17A水平在老年结肠癌患者中的表达情况。方法选择78例70岁以上老年结肠癌患者、同期健康体检的78例70岁以上老年健康者及78例青中年健康者作为研究对象,将78例老年结肠癌患者作为A组,78例老年健康者作为B组,78例青中年健康者作为C组。根据结肠癌的临床分期分为早期结肠癌(临床分期Ⅰ期和Ⅱ期)和中晚期结肠癌(临床分期Ⅲ期和Ⅳ期),早期结肠癌25例为A1组,中晚期结肠癌53例为A2组。比较各组患者外周血Th17细胞、血清IL-6和血清IL-17A水平。结果 A组患者的外周血Th17细胞水平高于B组和C组(P<0.05),B组患者的外周血Th17细胞水平高于C组(P<0.05);A1组患者的外周血Th17细胞水平高于A2组(P<0.05)。A组患者的血清IL-6水平高于B组和C组(P<0.05),B组患者的血清IL-6水平高于C组(P<0.05);A1组患者的血清IL-6水平高于A2组(P<0.05)。A组和B组患者的血清IL-17A水平高于C组(P<0.05),A组和B组患者血清IL-17A水平比较差异没有统计学意义(P>0.05);A1组和A2组患者的血清IL-17A水平比较差异没有统计学意义(P>0.05)。结论外周血Th17细胞、血清IL-6和IL-17A水平与老年结肠癌的发生相关,外周血Th17细胞和血清IL-6和老年结肠癌的分期明显相关。

引用

页码：2179 / 2181

页数：3

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