蛋白激酶Cε的结构特点和生理、病理作用

被引:2
作者
王芳
曹西南
机构
[1] 昆明医学院生物化学教研室
[2] 昆明医学院分子生物学研究室
关键词
缺血; 基因敲除; 乙型蛋白激酶; 转基因; 肿瘤;
D O I
暂无
中图分类号
R363 [病理生理学];
学科分类号
100104 ;
摘要
蛋白激酶C(PKCε)归为新型PKC亚家族,其特点为非钙依赖而对佛波酯或二脂酰甘油(DAG)敏感的Ser/Thr蛋白激酶。PKCε在细胞内的区域化定位取决于第二信使和一些信号蛋白因子,这类蛋白因子能对G蛋白偶连受体、酪氨酸激酶受体和酪氨酸激酶偶连受体作出应答。PKCε调节各种生理功能包括神经、内分泌、外分泌、炎症和免疫系统活化。PKCε控制性活化在心肌缺血和Alzheimer′s病中起到积极作用,而非控制、长时间活性可导致严重疾病,如恶性肿瘤和糖尿病的发生。本文就PKCε亚细胞定位及生理、病理方面的近期研究作一综述。
引用
收藏
页码:307 / 309
页数:3
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