大鼠实验性脑梗塞的定量检测

被引：8

作者：

秦震

孙国华

张福林

徐嘉芳

机构：

[1] 上海医科大学神经病学研究所

[2] 中国科学院上海脑研究所

来源：

中国神经精神疾病杂志 | 1990年 / 02期

关键词：

脑梗塞体积; MCA; 大鼠; 实验性脑梗塞; 定量检测;

D O I：

暂无

中图分类号：

学科分类号：

摘要：

报告1种测定实验性脑梗塞体积的方法。以戊巴此妥钠腹腔注射麻醉大鼠后,电凝大脑中动脉主干。7日后将动物处死、灌注固定。作前脑连续切片,间隔500或1000μ取8至10张切片。放大描绘后通过图形输入板及自编生物图形参数测量软件输入电脑,计算出脑梗塞体积为29.2±8.2mm3,占前脑体积的8±1.6％。

引用

页码：88 / 89+87 +87

页数：3

共 7 条

[1] Yamori Y,et al.Pathogenetic similarity of strokes in stroke-prone spontaneously hypertensive rats and humans. Stroke . 1976
[2] Gotoh O,et al.Nimodipine and the hemodynamic and histopathological consequences of middle cerebral artery occlusion in the rat. Journal of Cerebral Blood Flow and Metabolism . 1986
[3] Graham DI.Editorial: Focal cerebral infarction. Journal of Cerebral Blood Flow and Metabolism . 1988
[4] Mohamed AA,et al.Effect of pretreatment with the calcium antagenist nimodipine on local cerebral blood flow and histopathology after middle cerebral artery occlusion. Annals of Neurology . 1985
[5] Martz D,et al.Allopurinol and dimethylthiourea reduce brain infarction following middle cerebral artery occlusion in rats. Stroke . 1989
[6] Osborne KA,et al.Quantitative assessment of early brain damage in a rat model of focal cerebral ischaemia. Journal of Neurology Neurosurgery and Psychiatry . 1987
[7] Duverger D & Mackenzie ET.The quantification of cerebral infarction following focal ischaemia in the rat: Influence of strain, arterial pressure, blood glucose concentration, and age. Journal of Cerebral Blood Flow and Metabolism . 1988

← 1 →