肿瘤坏死因子-α和白细胞介素-8与慢性阻塞性肺疾病发病机制的关系

被引：16

作者：

王东

张东岳

机构：

[1] 兰州市第一人民医院呼吸科

来源：

中国生物制品学杂志 | 2010年 / 23卷 / 06期

关键词：

慢性阻塞性肺疾病; 肿瘤坏死因子-α; 白细胞介素-8;

D O I：

10.13200/j.cjb.2010.06.110.wangd.024

中图分类号：

R563.9 [其他];

学科分类号：

1002 ; 100201 ;

摘要：

慢性阻塞性肺疾病(Chronic obstructive pulmonary disease,COPD)是呼吸系统常见疾病,近期研究表明,一些细胞因子如肿瘤坏死因子-α(TNF-α)和白细胞介素-8(IL-8)与COPD的发生密切相关。TNF-α和IL-8作为主要的炎性递质参与了介导气道炎症反应,二者相互作用、相互促进、加速局部炎症的发生发展,可导致气道结构的重塑和气流阻塞的形成,最终对COPD的发生、发展产生影响。本文就TNF-α和IL-8与COPD发病机制的关系作一综述。

引用

页码：665 / 668

页数：4

共 28 条

[1]

Regulation of proinflammatory cytokines in human lung epithelial cells infected with Mycoplasma pneumoniae. Yang J, Hooper WC, Phillips DJ, et al. Infection and Immunity . 2002

[2]

TNF-α receptor -1-Antitrypsin and a broad deficient mice reveal divergent roles for p55 and p75 in several models antiof inflammation. Peschon JJ,Torrance DS,Stocking KL, et al. J Immunol . 1998

[3]

Association of tumor necrosis factor-alpha gene promoter polymorphism with low attenuation areas on high-resolution CT in patients with COPD. Sakao S, Tatsumi K, Igari H, et al. Chest . 2002

[4] 白介素-8与慢性阻塞性肺疾病 [J].

侯静静 ;

朱蕾 .

国外医学呼吸系统分册., 2005, (06) :427-429

[5] 细胞因子在慢性阻塞性肺疾病发病中的作用 [J].

刘景艳 ;

修清玉 .

国外医学呼吸系统分册., 2005, (06) :420-422

[6]

Association of IL8, CXCR2 and TNF-α polymorphisms and airway disease[J] . Melanie C. Matheson,Justine A. Ellis,Joan Raven,E. Haydn Walters,Michael J. Abramson. &nbspJournal of Human Genetics . 2006 (3)

[7] Neutrophil gelatinase B and chemokines in leukocytosis and stem cell mobilization [J].

Starckx, S ;

Van den Steen, PE ;

Wuyts, A ;

Van Damme, J ;

Opdenakker, G .

LEUKEMIA & LYMPHOMA, 2002, 43 (02) :233-241

[8]

Association of tumor necrosis factor alpha gene promoter polymorphism with the presence of chronic obstructive pulmonary disease. Sakao S, Tatsumi K, Igari H, et al. American Journal of Respiratory and Critical Care Medicine . 2001

[9]

Local and system ic inflammation in patients with chronic obstructive pulmonary disease:soluble tumor necrosis factor receptors are increased in sputum. Vernooy J H, Kucukaycan M, Jacobs J A, et al. American Journal of Respiratory and Critical Care Medicine . 2002

[10]

Tumor necrosis factor-alpha increases airway responsiveness and sputum neutrophilia in normal human subjects. P.S. Thomas,D.H. Yates,P.J. Barnes. American Journal of Respiratory and Critical Care Medicine . 1995

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