甘草次酸及其衍生物的抗炎机制

被引：53

作者：

董方圆

王杰军

机构：

[1] 第二军医大学长征医院肿瘤科

来源：

大连医科大学学报 | 2014年 / 36卷 / 02期

关键词：

甘草次酸; 抗炎; 衍生物;

D O I：

暂无

中图分类号：

R285.5 [中药实验药理];

学科分类号：

100806 [中药药理学];

摘要：

甘草次酸是甘草的主要活性成分。近年来对甘草次酸及其生物药理作用的研究不断深入,逐渐明确其药理作用,它具有抗炎、抗氧化、抗肿瘤、抗菌、抗病毒等多种作用。就抗炎来说,甘草次酸及其衍生物可以通过多个靶点直接抑制炎性细胞因子和炎性介质的产生,也可以通过增强类固醇激素的活性等机制间接地发挥其抗炎功能。本文结合近年来国内外的研究现状对甘草次酸及衍生物的抗炎作用进行综述。

引用

页码：195 / 197

页数：3

共 17 条

[1]

Induction of heme oxygenase-1 and inhibition of TPA-induced matrix metalloproteinase-9 expression by andrographolide in MCF-7 human breast cancer cells [J].

Chao, Che-Yi ;

Lii, Chong-Kuei ;

Hsu, Ya-Ting ;

Lu, Chia-Yang ;

Liu, Kai-Li ;

Li, Chien-Chun ;

Chen, Haw-Wen .

CARCINOGENESIS, 2013, 34 (08) :1843-1851

[2]

Therapeutic Effects of Glycyrrhizic Acid [J].

Ming, Lee Jia ;

Yin, Adeline Chia Yoke .

NATURAL PRODUCT COMMUNICATIONS, 2013, 8 (03) :415-418

[3]

Discovery of a Potential Anti-Inflammatory Agent: 3-Oxo-29-noroleana-1,9(11),12-trien-2,20-dicarbonitrile [J].

You, Ran ;

Long, Wenyan ;

Lai, Zhonghui ;

Sha, Lei ;

Wu, Kai ;

Yu, Xing ;

Lai, Yisheng ;

Ji, Hui ;

Huang, Zhangjian ;

Zhang, Yihua .

JOURNAL OF MEDICINAL CHEMISTRY, 2013, 56 (05) :1984-1995

[4]

A Novel Transdermal Fomulation of 18β-Glycyrrhetic Acid with Lysine for Improving Bioavailability and Efficacy [J].

Li, S. ;

Qiu, Y. Q. ;

Zhang, S. H. ;

Gao, Y. H. .

SKIN PHARMACOLOGY AND PHYSIOLOGY, 2012, 25 (05) :257-268

[5]

Glycyrrhizic acid and 18β-glycyrrhetinic acid recover glucocorticoid resistance via PI3K-induced AP1; CRE and NFAT activation.[J].Tzu-Chien Kao;Chi-Hao Wu;Gow-Chin Yen.Phytomedicine.2012,

[6]

Inhibitory Effects of Glycyrrhetinic Acid on DNA Polymerase and Inflammatory Activities.[J].Tsukasa Ishida;Yoshiyuki Mizushina;Saori Yagi;Yasuhiro Irino;Shin Nishiumi;Ikuya Miki;Yasuyuki Kondo;Shigeto Mizuno;Hiromi Yoshida;Takeshi Azuma;Masaru Yoshida;Y. Ohta.Evidence-Based Complementary and Alternative Medicine.2011,

[7]

Characterization of activity and binding mode of glycyrrhetinic acid derivatives inhibiting 11β-hydroxysteroid dehydrogenase type 2.[J].Denise V. Kratschmar;Anna Vuorinen;Thierry Da Cunha;Gerhard Wolber;Dirk Classen-Houben;Otto Doblhoff;Daniela Schuster;Alex Odermatt.Journal of Steroid Biochemistry and Molecular Biology.2011, 1

[8]

18β-Glycyrrhetic Acid Inhibits Immune Activation Triggered by HMGB1, a Pro-inflammatory Protein Found in the Tear Fluid during Conjunctivitis and Blepharitis [J].

Cavone, Leonardo ;

Muzzi, Mirko ;

Mencucci, Rita ;

Sparatore, Bianca ;

Pedrazzi, Marco ;

Moroni, Flavio ;

Chiarugi, Alberto .

OCULAR IMMUNOLOGY AND INFLAMMATION, 2011, 19 (03) :180-185

[9]

18α-glycyrrhetinic acid targets prostate cancer cells by down-regulating inflammation-related genes [J].

Shetty, Aditya V. ;

Thirugnanam, Sivasakthivel ;

Dakshinamoorthy, Gajalakshmi ;

Samykutty, Abhilash ;

Zheng, Guoxing ;

Chen, Aoshuang ;

Bosland, Maarten C. ;

Kajdacsy-Balla, Andre ;

Gnanasekar, Munirathinam .

INTERNATIONAL JOURNAL OF ONCOLOGY, 2011, 39 (03) :635-640

[10]

Glycyrrhizic Acid and 18β-Glycyrrhetinic Acid Modulate Lipopolysaccharide-lnduced Inflammatory Response by Suppression of NF-kB through PI3K p110δ and p110γ Inhibitions.[J].Chung-Yi Wang;Tzu-Chien Kao;Wen-Hsieh Lo.Journal of Agricultural and Food Chemistry.2011, 14

← 1 2 →