放化疗性口腔黏膜炎动物模型研究进展

被引：4

作者：

邹晓龙 ^{[1
]}

陈媛 ^{[1
]}

王艳 ^{[1
]}

王建涛 ^{[2
]}

机构：

[1] 口腔疾病研究国家重点实验室国家口腔疾病临床医学研究中心四川大学华西口腔医院

[2] 生物治疗国家重点实验室四川大学华西医院肺癌中心四川大学华西医院放疗中心

来源：

口腔疾病防治 | 2020年 / 28卷 / 05期

关键词：

口腔黏膜炎; 放疗; 化疗; 动物模型; 评估方法; 小鼠; 大鼠; 5-氟尿嘧啶; 铯;

D O I：

暂无

中图分类号：

R-332 [医用实验动物学]; R730.5 [肿瘤治疗学]; R781.5 [口腔粘膜病];

学科分类号：

100201 [内科学]; 100214 [肿瘤学]; 100402 [劳动卫生与环境卫生学];

摘要：

由放疗和(或)化疗诱发的口腔黏膜炎症,可能导致患者疼痛、说话吞咽困难、局部和全身感染风险增高,甚至中断抗癌治疗,严重影响患者生活质量。放化疗性口腔黏膜炎的发病机制复杂而且防治较为困难,而动物模型在探究放化疗性口腔黏膜炎的发病机制以及探索更好的防治方法中发挥了重要作用,本文就以现有的放化疗性口腔黏膜炎动物模型的复制及评估方法予以综述。文献复习结果表明,国内外采用小鼠、大鼠、金仓鼠等动物来复制动物模型;放疗诱发的口腔黏膜炎的诱导方法有仅采用X射线设备对动物进行局部单剂量照射或局部分割照射,或照射时辅助使用化疗药物5-氟尿嘧啶或顺铂,也可以采用137铯作为放射源进行局部照射;单纯使用化疗药物5-氟尿嘧啶诱发的口腔黏膜炎一般症状较轻,因此多采用5-氟尿嘧啶联合机械刺激或乙酸进行诱导;评估放化疗性口腔黏膜炎的方法主要为大体样本观察及组织病理学观察。

引用

页码：322 / 326

页数：5

共 11 条

[1]

Chemotherapy Induces Oral Mucositis in Mice Without Additional Noxious Stimuli [J].

Bertolini, M. ;

Sobue, T. ;

Thompson, A. ;

Dongari-Bagtzoglou, A. .

TRANSLATIONAL ONCOLOGY, 2017, 10 (04) :612-620

[2]

Intra-oral administration of rebamipide liquid prevents tongue injuries induced by X-ray irradiation in rats [J].

Nakashima, Takako ;

Uematsu, Naoya ;

Sakurai, Kazushi .

SUPPORTIVE CARE IN CANCER, 2017, 25 (07) :2205-2213

[3]

Protective effect of Salvia miltiorrhiza Bunge on 5-fluorouracil-induced oral mucositis [J].

Kim, Do Rim ;

Kim, Jinsung ;

Oh, Ja Young ;

Kim, Ha Young ;

Kim, Young Joo ;

Chang, Mun Seog .

INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE, 2017, 40 (01) :39-46

[4]

Early inflammatory changes in radiation-induced oral mucositis.[J].Sylvia Gruber;Eva Bozsaky;Eva Roitinger;Karoline Schwarz;Margret Schmidt;Wolfgang D?rr.Strahlentherapie und Onkologie.2017, 6

[5]

The therapeutic effects of apigenin and dexamethasone on 5‐fluorouracil‐induced oral mucositis – a pilot study using a Syrian hamster model.[J].Patricia Molina Prats;Francisco Gómez Garcia;Francisco Martinez Diaz;Rui Amaral Mendes;Pia Lopez‐ Jornet.Journal of Oral Pathology & Medicine.2017, 2

[6]

A PPAR gamma agonist protects against oral mucositis induced by irradiation in a murine model [J].

Monica, Mangoni ;

Mariangela, Sottili ;

Chiara, Gerini ;

Isacco, Desideri ;

Cinzia, Bastida ;

Stefania, Pallotta ;

Francesca, Castiglione ;

Pierluigi, Bonomo ;

Icro, Meattini ;

Daniela, Greto ;

Emanuela, Olmetto ;

Francesca, Terziani ;

Carlotta, Becherini ;

Camilla, Delli Paoli ;

Laura, Trombetta ;

Mauro, Loi ;

Giampaolo, Biti ;

Lorenzo, Livi .

ORAL ONCOLOGY, 2017, 64 :52-58

[7]

Dosimetric study of photobiomodulation therapy in 5-FU-induced oral mucositis in hamsters [J].

Cotomacio, Claudia Carrara ;

Campos, Luana ;

de Souza, Douglas Nesadal ;

Arana-Chavez, Victor Elias ;

Simoes, Alyne .

JOURNAL OF BIOMEDICAL OPTICS, 2017, 22 (01)

[8]

The traditional Japanese medicine hangeshashinto alleviates oral ulcer-induced pain in a rat model.[J].Suzuro Hitomi;Kentaro Ono;Kiichiro Yamaguchi;Kiyoshi Terawaki;Ryota Imai;Kunitsugu Kubota;Yuji Omiya;Tomohisa Hattori;Yoshio Kase;Kiyotoshi Inenaga.Archives of Oral Biology.2016,

[9]

Local hypoxia in oral mucosa (mouse) during daily fractionated irradiation – Effect of pentoxifylline.[J].Sylvia Gruber;Daniel Hamedinger;Eva Bozsaky;Margret Schmidt;Kathrin Wolfram;Julia Haagen;Bettina Habelt;Martin Puttrich;Wolfgang Dörr.Radiotherapy and Oncology.2015, 3

[10]

A Novel Peptide to Treat Oral Mucositis Blocks Endothelial and Epithelial Cell Apoptosis [J].

Wu, Xiaoyan ;

Chen, Peili ;

Sonis, Stephen T. ;

Lingen, Mark W. ;

Berger, Ann ;

Toback, F. Gary .

INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS, 2012, 83 (03) :E409-E415

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