硫酸镍对大鼠心肝肾ATPase毒性的实验研究

被引：18

作者：

孙应彪

朱玉真

机构：

[1] 兰州医学院预防医学系!甘肃兰州

来源：

中国职业医学 | 2001年 / 03期

关键词：

nickel sulfate; Na +·K + ATPase; Ca 2+ ATPase;

D O I：

暂无

中图分类号：

R114 [卫生毒理];

学科分类号：

100405 ;

摘要：

Objective To inquire into the mechanism of toxic effect of nickel sulfate (NiSO 4) on heart, liver and kidney.Methods Several groups of rats were exposed to NiSO 4 at dose of 2.5,5 0, 10.0 mg/kg through intraperitoneal infection for 10 days, the cell membrane of myocardium, liver and renal tubules were prepared to assess the activity of Na +·K + ATPase, Ca 2+ ATPase with spectrophotometric assay. Results The result showed that NiSO 4 was able to inhibit obviously the activity of Na +·K + ATPase, Ca 2+ ATPase of the three kinds of cell membrane, and its inhibitiue effect was shown to be the strongest in kidney and the weakest in liver.Conclusion The damage on rat's heart, liver and kidney by NiSO 4 could be related to the inhibitive activity of cell membrane ATPase. However, the mechanism of toxic effect of nickel sulfate on heart, liver and kidney should be studied further.

引用

页码：27 / 28

页数：2