中国糖尿病防治研究的现状和挑战

被引:201
作者
康继宏
宁光
吴家睿
管又飞
机构
[1] 北京大学医学部生理及病生理学系
[2] 上海交通大学医学院附属瑞金医院
[3] 中国科学院上海生命科学研究院
[4] 普林斯顿大学,第一校园中心
关键词
糖尿病; 血管合并症; 胰岛素抵抗; 易感基因; 糖脂代谢毒性;
D O I
暂无
中图分类号
R587.1 [糖尿病];
学科分类号
100201 [内科学];
摘要
糖尿病,特别是2型糖尿病,已成为一个全球性的健康威胁。随着国内人民生活水平的提高,膳食结构和生活方式的改变导致了与糖脂代谢紊乱相关疾病的迅猛增加。其中,糖尿病人群已接近1亿,糖尿病前期人群大约2亿。糖尿病相关的合并症,如大血管病变、微血管病变和肿瘤已成为国内人群主要的致死和致残原因。我国糖尿病患者人数急剧增多的原因可能是遗传和环境因素综合作用的结果,涉及易感基因、表观遗传作用、糖脂代谢紊乱等众多因素。近年来,我国在糖尿病流行病学调查、遗传易感基因确定、膳食营养因子作用、胰岛素分泌调节、胰岛素敏感性调控、糖脂代谢紊乱机制、合并症发生机制和防治策略制定方面取得了长足进步。然而,糖尿病危害的消除还有赖于政府、社会、医药界及患者的共同努力。
引用
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页码:1 / 24
页数:24
相关论文
共 13 条
[1]
Implications of Using Hemoglobin A1C for Diagnosing Diabetes Mellitus [J].
Malkani, Samir ;
Mordes, John P. .
AMERICAN JOURNAL OF MEDICINE, 2011, 124 (05) :395-401
[2]
Leucine Deprivation Increases Hepatic Insulin Sensitivity via GCN2/mTOR/S6K1 and AMPK Pathways [J].
Xiao, Fei ;
Huang, Zhiying ;
Li, Houkai ;
Yu, Junjie ;
Wang, Chunxia ;
Chen, Shanghai ;
Meng, Qingshu ;
Cheng, Ying ;
Gao, Xiang ;
Li, Jia ;
Liu, Yong ;
Guo, Feifan .
DIABETES, 2011, 60 (03) :746-756
[3]
Long-term effects of a randomised trial of a 6-year lifestyle intervention in impaired glucose tolerance on diabetes-related microvascular complications: the China Da Qing Diabetes Prevention Outcome Study [J].
Gong, Q. ;
Gregg, E. W. ;
Wang, J. ;
An, Y. ;
Zhang, P. ;
Yang, W. ;
Li, H. ;
Li, H. ;
Jiang, Y. ;
Shuai, Y. ;
Zhang, B. ;
Zhang, J. ;
Gerzoff, R. B. ;
Roglic, G. ;
Hu, Y. ;
Li, G. ;
Bennett, P. H. .
DIABETOLOGIA, 2011, 54 (02) :300-307
[4]
Costs to Medicare of the Informatics for Diabetes Education and Telemedicine (IDEATel) Home Telemedicine Demonstration Findings from an independent evaluation [J].
Moreno, Lorenzo ;
Dale, Stacy B. ;
Chen, Arnold Y. ;
Magee, Carol A. .
DIABETES CARE, 2009, 32 (07) :1202-1204
[5]
The long-term effect of lifestyle interventions to prevent diabetes in the China Da Qing Diabetes Prevention Study: a 20-year follow-up study [J].
Li, Guangwei ;
Zhang, Ping ;
Wang, Jinping ;
Gregg, Edward W. ;
Yang, Wenying ;
Gong, Qiuhong ;
Li, Hui ;
Li, Hongliang ;
Jiang, Yayun ;
An, Yali ;
Shuai, Ying ;
Zhang, Bo ;
Zhang, Jingling ;
Thompson, Theodore J. ;
Gerzoff, Robert B. ;
Roglic, Gojka ;
Hu, Yinghua ;
Bennett, Peter H. .
LANCET, 2008, 371 (9626) :1783-1789
[6]
Protein kinase Cζ and glucose uptake [J].
Liu, Li-Zhong ;
He, Ai-Bin ;
Liu, Xiao-Jun ;
Li, Yi ;
Chang, Yong-Sheng ;
Fang, Fu-De .
BIOCHEMISTRY-MOSCOW, 2006, 71 (07) :701-706
[7]
Herbal or natural medicines as modulators of peroxisome proliferator-activated receptors and related nuclear receptors for therapy of metabolic syndrome [J].
Huang, THW ;
Kota, BP ;
Razmovski, V ;
Roufogalis, BD .
BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY, 2005, 96 (01) :3-14
[8]
Recent advances in physiological and pathological significance of NAD<sup>+</sup> metabolites: roles of poly(ADP-ribose) and cyclic ADP-ribose in insulin secretion and diabetogenesis.[J].Hiroshi Okamoto;Shin Takasawa.Nutrition Research Reviews.2003, 2
[9]
Pancreatic duodenal homeobox (PDX-1) in health and disease [J].
Melloul, D ;
Tsur, A ;
Zangen, D .
JOURNAL OF PEDIATRIC ENDOCRINOLOGY & METABOLISM, 2002, 15 (09) :1461-1472
[10]
A genome-wide search for Type II diabetes susceptibility genes in Chinese Hans [J].
Luo, TH ;
Zhao, Y ;
Li, G ;
Yuan, WT ;
Zhao, JJ ;
Chen, JL ;
Huang, W ;
Luo, M .
DIABETOLOGIA, 2001, 44 (04) :501-506