阿尔茨海默病与肠道菌群的关系及菌群调节对其防治的展望

被引：22

作者：

周珂新

徐雷艇

马银娟

周佳思

戴嘉佳

梁丽丽

魏华

机构：

[1] 宁波大学医学院病理学与病原生物学实验室浙江省病理生理学技术研究重点实验室糖尿病研究中心

来源：

中国药理学与毒理学杂志 | 2016年 / 30卷 / 11期

基金：

浙江省自然科学基金;

关键词：

阿尔茨海默病; 肠道菌群; 代谢物;

D O I：

暂无

中图分类号：

R749.16 [];

学科分类号：

摘要：

随着人类寿命的延长,阿尔茨海默病(AD)患者的数量不断增加,而AD的发病机制仍不明确,对该病的防治尚缺乏有效方法。近年来,肠道菌群在机体健康领域的重要性被逐渐解析,也为AD提供一个崭新的研究领域。AD患者存在中枢神经系统慢性炎症、脑内神经递质5-羟色胺、神经营养因子等表达下降以及肠道菌群结构改变。肠道菌群可引发机体慢性炎症,产生神经毒性物质,并且与AD高危因素肥胖和2型糖尿病等代谢性疾病的发生相关,提示AD与肠道菌群的相关性。益生菌、益生元与中药等肠道菌群调节制剂可降低炎症以及糖尿病等代谢综合征的发生,提高脑内神经递质5-羟色胺和神经营养因子的水平,改善认知功能,肠道菌群调节有望成为防治AD的新方法。

引用

页码：1198 / 1205

页数：8

共 23 条

[1]

Inflammatory Cytokines and Alzheimer's Disease: A Review from the Perspective of Genetic Polymorphisms [J].

Su, Fan ;

Bai, Feng ;

Zhang, Zhijun .

NEUROSCIENCE BULLETIN, 2016, 32 (05) :469-480

[2]

Gut microbiota and liver diseases [J].

Minemura, Masami ;

Shimizu, Yukihiro .

WORLD JOURNAL OF GASTROENTEROLOGY, 2015, 21 (06) :1691-1702

[3]

Acceleration of Amyloidosis by Inflammation in the Amyloid-Beta Marmoset Monkey Model of Alzheimer’s Disease.[J].Ingrid H. Philippens;Paul R. Ormel;Guus Baarends;Maja Johansson;Ed J. Remarque;Magnus Doverskog.Journal of Alzheimer's Disease.2016, 1

[4]

Technological and safety properties of newly isolated GABA-producing Lactobacillus futsaii strains [J].

Sanchart, C. ;

Rattanaporn, O. ;

Haltrich, D. ;

Phukpattaranont, P. ;

Maneerat, S. .

JOURNAL OF APPLIED MICROBIOLOGY, 2016, 121 (03) :734-745

[5]

Triptolide Rescues Spatial Memory Deficits and Amyloid-? Aggregation Accompanied by Inhibition of Inflammatory Responses and MAPKs Activity in APP/PS1 Transgenic Mice.[J].Yan-Qiu Cui;Qi Wang;Dong-Mei Zhang;Jun-Ya Wang;Bing Xiao;Yan Zheng;Xiao-Min Wang.Current Alzheimer Research.2016, 3

[6]

Microbes and Alzheimer's Disease [J].

Itzhaki, Ruth F. ;

Lathe, Richard ;

Balin, Brian J. ;

Ball, Melvyn J. ;

Bearer, Elaine L. ;

Braak, Heiko ;

Bullido, Maria J. ;

Carter, Chris ;

Clerici, Mario ;

Cosby, S. Louise ;

Del Tredici, Kelly ;

Field, Hugh ;

Fulop, Tamas ;

Grassi, Claudio ;

Griffin, W. Sue T. ;

Haas, Jurgen ;

Hudson, Alan P. ;

Kamer, Angela R. ;

Kell, Douglas B. ;

Licastro, Federico ;

Letenneur, Luc ;

Lovheim, Hugo ;

Mancuso, Roberta ;

Miklossy, Judith ;

Otth, Carola ;

Palamara, Anna Teresa ;

Perry, George ;

Preston, Christopher ;

Pretorius, Etheresia ;

Strandberg, Timo ;

Tabet, Naji ;

Taylor-Robinson, Simon D. ;

Whittum-Hudson, Judith A. .

JOURNAL OF ALZHEIMERS DISEASE, 2016, 51 (04) :979-984

[7]

Calcium supplementation modulates gut microbiota in a prebiotic manner in dietary obese mice [J].

Chaplin, Alice ;

Parra, Pilar ;

Laraichi, Sarah ;

Serra, Francisca ;

Palou, Andreu .

MOLECULAR NUTRITION & FOOD RESEARCH, 2016, 60 (02) :468-480

[8]

Effect of probiotics on glucose metabolism in patients with type 2 diabetes: A meta-analysis of randomized controlled trials.[J].Qingqing Zhang;Yucheng Wu;Xiaoqiang Fei.Medicina.2015,

[9]

Herpes Simplex Virus Type 1 and Other Pathogens are Key Causative Factors in Sporadic Alzheimer's Disease [J].

Harris, Steven A. ;

Harris, Elizabeth A. .

JOURNAL OF ALZHEIMERS DISEASE, 2015, 48 (02) :319-353

[10]

Administration of Lactobacillus helveticus NS8 improves behavioral; cognitive; and biochemical aberrations caused by chronic restraint stress.[J].S. Liang;T. Wang;X. Hu;J. Luo;W. Li;X. Wu;Y. Duan;F. Jin.Neuroscience.2015,

← 1 2 3 →