豚鼠原发性骨性关节炎的血清IGF-I检测及意义

被引：13

作者：

蓝旭

刘雪梅

葛宝丰

许建中

不详

机构：

[1] 兰州军区总医院骨科研究所!兰州

[2] 第三军医大学西南医院骨科!重庆

来源：

中国矫形外科杂志 | 2000年 / 07期

关键词：

骨性关节炎; 胰岛素样生长因子I; 放射免疫测定;

D O I：

暂无

中图分类号：

R684.3 [关节炎];

学科分类号：

1002 ; 100210 ;

摘要：

目的 :探讨胰岛素样生长因子I(IGF -I)在豚鼠原发性骨性关节炎早期病变机制中的作用。方法 :Hartley雌性豚鼠 3 0只 ,以出生后 1、3、7月分 3组 ,每组 10只。观察豚鼠膝关节软骨降解情况 ,用线性相关分析法分析各组变量间的相关关系。结果 :3个月组豚鼠关节软骨即有严重降解 ,其血清IGF -I水平随年龄段的增长而升高 ,各组间差异非常显著 ( p <0 .0 1)。 3组豚鼠血清IGF -I与其年龄呈显著正相关 (r =0 .5 6,p <0 .0 0 1)。结论 :IGF -I是关节软骨生长发育的重要调节因子 ,IGF -I的代谢可能与原发性骨关节炎的发病机制有关。

引用

页码：47 / 48

页数：2

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