吸烟与肝癌关系的Meta分析

被引：40

作者：

刘银梅

沈月平

刘娜

胡文斌

刘雯

机构：

[1] 江苏苏州大学医学部放射医学与公共卫生学院流行病与卫生统计教研室

来源：

现代预防医学 | 2010年 / 37卷 / 20期

关键词：

肝癌; 吸烟; Meta分析;

D O I：

暂无

中图分类号：

R735.7 [肝肿瘤];

学科分类号：

100112 [医学生物化学与分子生物学];

摘要：

[目的]采用Meta分析法探讨吸烟与肝癌发病的相关性,为进行人群健康教育和预防决策提供依据。[方法]以肝癌组与对照组人群是否吸烟的OR值为效应指标,根据一致性检验的结果,选择随机效应模型对OR值进行合并并进行偏倚评估。采用GLS法检验吸烟量与OR值的剂量反应关系。[结果]共查到符合要求的国内外文献50篇,病例和对照数分别为10228、22312例。经异质性检验,50项研究结果存在异质性(q=267.75,P﹤0.0001),经过随机效应模型估计,以不吸烟人群为参比组,吸烟人群患肝癌的合并OR值为1.43(95%CI1.25～1.63)。按地域(亚洲、中北美洲、欧洲)合并OR值(95%CI)分别为1.46(1.24～1.72)、1.65(1.29～2.10)和1.14(0.83～1.57),按国别(国内、国外)合并OR值(95%CI)为1.32(1.07～1.63)和1.51(1.28～1.78),按对照选取的人群(正常人、非肝癌病人)合并OR值(95%CI)为1.41(1.21～1.64)和1.44(1.18～1.75),按研究设计的类型(病例对照、巢式病例对照)合并OR值(95%CI)为1.47(1.29～1.68)和1.00(0.54～1.82),OR值较一致。随吸烟量增加,肝癌发生风险在增加,呈现显著剂量反应关系(Z=4.76,P﹤0.0001)。[结论]吸烟是肝癌发病的危险因素。

引用

页码：3801 / 3807+3815 +3815

页数：8

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