代谢组学方法的建立及其在药物安全评价中的应用

[1] Proton MRS of human prostatic fluid:correlations between citrate, spermine and myo-inositol and changes with disease. Lynch MJ,Nicholson JK. Prostate . 1997

[2] NMR of biofluids and pattern recognition-assessing the impact of NMR parameters on the principal component analysis of urine from rat and mouse. Potts BCM,Deese AJ,Stevens GJ,et al. Journal of Pharmaceutical and Biomedical Analysis . 2001

[3] The application of pattern recognition methods to the analysis and classification of toxicological data derived from NMR spectroscopy of urine. Gartland KPR,Beddell C,Lindon JC,et al. Molecular Pharmacology . 1991

[4] Metabonomics and genomic investigation if renal papillary necrosis ( RPN ). Thomas CE,Ryan TP,Gao H,et al. The Toxicologist . 2002

[5] Assessing the potential toxicity of new pharmaceutics. Johnson DE,Wolfgang GH. Current Topics Med Chem . 2001

[6] An NMR-based metabonomic approach to investigate the biochemical consequences of genetic strain differences-application to the C57BL10J and Alpk-ApfCD mouse. Gavaghan CL,Holmes E,Lenz E,et al. FEBS Letters . 2000

[7] Metabonomics: a platform for studying drug toxicity and gene function. Nicholson JK,Connelly J,Lindon JC,et al. Nature Reviews Drug Discovery . 2002

[8] Toxicoproteomics-a new preclinical tool. Bandara LR,Kennedy S. Drug Discovery Today . 2002

[9] Toxicogenomics: a new revolution in drug safety. Castle AL,Carver MP,Mendrick DL. Drug Discovery Today . 2002

[10] Metabonomic approaches to understanding the consequences of drug toxicity and gene function. Nicholson JK. The Toxicologist . 2002

[1] Proton MRS of human prostatic fluid:correlations between citrate, spermine and myo-inositol and changes with disease. Lynch MJ,Nicholson JK. Prostate . 1997

[2] NMR of biofluids and pattern recognition-assessing the impact of NMR parameters on the principal component analysis of urine from rat and mouse. Potts BCM,Deese AJ,Stevens GJ,et al. Journal of Pharmaceutical and Biomedical Analysis . 2001

[3] The application of pattern recognition methods to the analysis and classification of toxicological data derived from NMR spectroscopy of urine. Gartland KPR,Beddell C,Lindon JC,et al. Molecular Pharmacology . 1991

[4] Metabonomics and genomic investigation if renal papillary necrosis ( RPN ). Thomas CE,Ryan TP,Gao H,et al. The Toxicologist . 2002

[5] Assessing the potential toxicity of new pharmaceutics. Johnson DE,Wolfgang GH. Current Topics Med Chem . 2001

[6] An NMR-based metabonomic approach to investigate the biochemical consequences of genetic strain differences-application to the C57BL10J and Alpk-ApfCD mouse. Gavaghan CL,Holmes E,Lenz E,et al. FEBS Letters . 2000

[7] Metabonomics: a platform for studying drug toxicity and gene function. Nicholson JK,Connelly J,Lindon JC,et al. Nature Reviews Drug Discovery . 2002

[8] Toxicoproteomics-a new preclinical tool. Bandara LR,Kennedy S. Drug Discovery Today . 2002

[9] Toxicogenomics: a new revolution in drug safety. Castle AL,Carver MP,Mendrick DL. Drug Discovery Today . 2002

[10] Metabonomic approaches to understanding the consequences of drug toxicity and gene function. Nicholson JK. The Toxicologist . 2002