替吉奥联合奥沙利铂与替吉奥单药治疗老年晚期胃癌的临床比较研究

被引：16

作者：

张瑜

倪婷婷

张汉群

李馨

李杭

机构：

[1] 贵州省人民医院肿瘤科

来源：

肿瘤基础与临床 | 2015年 / 28卷 / 02期

关键词：

替吉奥; 奥沙利铂; 晚期胃癌; 老年患者; 疗效;

D O I：

暂无

中图分类号：

R735.2 [胃肿瘤];

学科分类号：

100112 [医学生物化学与分子生物学];

摘要：

目的比较替吉奥联合奥沙利铂与替吉奥单药治疗老年晚期胃癌的临床疗效及毒副反应。方法70例晚期胃癌老年患者随机分为2组,联合组37例予以替吉奥联合奥沙利铂化疗,单药组33例仅接受替吉奥治疗。结果与单药组比较,联合组治疗有效率和疾病控制率均显著提高(P<0.05),但不能延长患者生存时间和提高患者生活质量(P>0.05);同时,联合组毒副反应也相应增加,骨髓抑制、外周神经毒性发生率均明显升高(P<0.05)。结论与单用替吉奥比较,替吉奥联合奥沙利铂治疗老年晚期胃癌可提高临床疗效,但安全性、耐受性及生存获益仍需扩大样本量进一步研究。

引用

页码：108 / 110

页数：3

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