钾离子通道开放剂的药效团模型分析

被引：5

作者：

陈红明

周家驹

谢桂荣

庞素华

机构：

[1] 中国科学院计算机化学开放实验室!北京,,中国科学院计算机化学开放实验室!北京,,中国科学院计算机化学开放实验室!北京,,中国科学院计算机化学开放实验室!北京,

来源：

物理化学学报 | 1997年 / 02期

关键词：

钾离子通道开放剂; 比较分子场分析; QSAR;

D O I：

暂无

中图分类号：

O641 [结构化学];

学科分类号：

070304 ; 081704 ;

摘要：

In this paper, a set of ATP sensitive K+ channel openers (KCO), whose structure are different, were investigated with the aim to develope our previously defined KCO's pharmacophore model.To validate the effectiveness of the pharmacophore model, A comparative molecule field analysis (CoMFA) was proceeded, aligning the molecules according to the requirernent of the model, and good results were obtained. This pharmacophore model may be a start point to design new KCO compounds.

引用

页码：101 / 105

页数：5

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