镉对大鼠附睾的损伤及锌和维生素 E 的保护作用

被引：5

作者：

廖晓岗

李维信

机构：

[1] 重庆医科大学电镜室

来源：

解剖学报 | 1997年 / 03期

关键词：

镉,附睾,超微结构,锌,维生素E,大鼠;

D O I：

10.16098/j.issn.0529-1356.1997.03.024

中图分类号：

R-332 [医用实验动物学];

学科分类号：

1001 ;

摘要：

用透射电镜结合脂质过氧化物（ＬＰＯ）含量分析法，观察小剂量氯化镉（２ｍｇ／ｋｇ体重）腹腔内注射后１０ｍｉｎ至６０ｄ大鼠附睾头部的损伤改变及锌和维生素Ｅ（ＶＥ）的保护作用。结果表明：注射镉后３０ｍｉｎ，主细胞已出现超微结构改变；３～７ｄ时主细胞和管周组织及毛细血管退变加重；１５～３０ｄ时退变有所减轻；６０ｄ时主细胞有恢复趋势而管周组织增厚。镉注射后附睾管周组织内碱性磷酸酶（ＡｌＰａｓｅ）反应产物明显减少。锌和ＶＥ对镉所致的形态损伤和酶活性下降有保护作用，且锌的效果优于ＶＥ。本实验还证实镉可使附睾ＬＰＯ含量增高，ＶＥ能较好颉颃脂质过氧化作用。

引用

页码：96 / 101+132

页数：7

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