支链淀粉修饰双嘧达莫脂质体的制备及其在小鼠体内的组织分布

被引：7

作者：

程骥

朱家壁

杨泗兴

王长斌

机构：

[1] 中国药科大学药物制剂研究所

来源：

药学学报 | 2006年 / 03期

关键词：

支链淀粉; 双嘧达莫脂质体; 组织分布; 肺靶向;

D O I：

10.16438/j.0513-4870.2006.03.018

中图分类号：

R943 [制剂学]; R96 [药理学];

学科分类号：

100602 ; 100702 ; 100706 ;

摘要：

目的研究支链淀粉修饰双嘧达莫(D IP)脂质体的制备方法并考察其在小鼠体内的组织分布。方法采用薄膜-分散法制备普通D IP脂质体;合成两亲性的棕榈酰化支链淀粉并用其修饰D IP脂质体;比较修饰前后包封率、zeta电位、平均粒径和径距的变化;采用反相高效液相法测定小鼠组织中的D IP浓度。结果修饰后D IP脂质体的包封率降低,zeta电位增加,平均粒径和径距无明显变化;普通脂质体可以增强D IP在肺部、肝脏和脾脏的分布,而较之普通脂质体,支链淀粉修饰的脂质体可以进一步增加肺部D IP水平,同时减少D IP在肝脏和脾脏的分布,并延长在肺部的滞留时间。结论与普通脂质体和注射液比较,支链淀粉修饰的脂质体可以改变D IP在小鼠体内的组织分布,具有显著的肺靶向性。

引用

页码：277 / 281

页数：5

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