非酒精性脂肪性肝病动物模型研究进展

被引：14

作者：

赵晓华

梁伟海

李伦

曹丽爽

吕志平

机构：

[1] 南方医科大学中医药学院

来源：

中华中医药杂志 | 2015年 / 30卷 / 07期

关键词：

非酒精性脂肪性肝病; 动物模型; 斑马鱼; 综述;

D O I：

暂无

中图分类号：

R-332 [医用实验动物学]; R575 [肝及胆疾病];

学科分类号：

100201 [内科学]; 100402 [劳动卫生与环境卫生学];

摘要：

非酒精性脂肪性肝病(NAFLD)是一种与胰岛素抵抗(IR)和遗传易感密切相关的代谢应激性肝脏损伤,其病理学改变与酒精性肝病(ALD)相似,但患者无过量饮酒史。NAFLD是21世纪全球重要的公共健康问题之一,亦是我国愈来愈重视的慢性肝病问题。文章就目前国内外常用的与人类相似的NAFLD动物模型,总结了大鼠、小鼠和斑马鱼营养失调性、药物毒物刺激性、特殊品系及复合因素诱导等模型的造模方法、效果及优缺点,同时对其前景进行了展望。

引用

收藏

页码：2441 / 2444

页数：4

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