肝衰竭预后危险因素及预后模型建立的研究

被引：34

作者：

汤伟亮

赵钢德

董志霞

项晓刚

王晖

周惠娟

桂红莲

郭斯敏

庄焱

谢青

机构：

[1] 上海交通大学医学院附属瑞金医院感染科

来源：

传染病信息 | 2011年 / 24卷 / 03期

关键词：

肝功能衰竭; 预后,危险因素; Logistic回归分析;

D O I：

暂无

中图分类号：

R575.3 [肝功能衰竭];

学科分类号：

100201 [内科学];

摘要：

目的探讨影响肝衰竭预后的危险因素,并建立其预后模型。方法回顾性调查2006年6月—2008年12月我科收治的252例肝衰竭患者的临床资料。采用多因素Logistic回归分析,得出相应的独立危险因素,并建立预后模型。结果多因素Logistic回归分析显示,患者年龄、肝性脑病、上消化道出血、感染、TBIL、PT是影响肝衰竭患者预后的独立危险因素。对所得出的独立危险因素建立肝衰竭患者的预后判断模型,计算预后指数并绘制受试者工作特征曲线,其曲线下面积为0.924(95%CI0.892,0.957)。结论年龄、肝性脑病、上消化道出血、感染、TBIL、PT是影响肝衰竭患者预后的独立危险因素。本研究初步建立预后模型能够较为准确地预测肝衰竭患者的短期预后,是一个较为理想的肝衰竭预后评估系统。

引用

页码：159 / 162

页数：4

共 10 条

[1]

Prognostic factors for chronic severe hepatitis and construction of a prognostic model.[J]..Hepatobiliary & Pancreatic Diseases International.2008, 01

[2]

肝衰竭诊疗指南 [J].

Liver Failure and Artificial Liver Group ;

Chinese Society of Infectious Diseases ;

Chinese Medical Association ;

Severe Liver Diseases and Artificial Liver Group ;

Chinese Society of Hepatology ;

Chinese Medical Association. .

中华肝脏病杂志, 2006, (09) :643-646

[3]

Critical Management Decisions in Patients With Acute Liver Failure [J].

Stravitz, R. Todd .

CHEST, 2008, 134 (05) :1092-1102

[4]

Artificial and Bioartificial Liver Support.[J].Travis McKenzie;Joseph Lillegard;Scott Nyberg.Semin Liver Dis.2008, 02

[5]

Role of liver transplantation in acute liver failure [J].

Liou, Iris W. ;

Larson, Anne M. .

SEMINARS IN LIVER DISEASE, 2008, 28 (02) :201-209

[6]

Assessment of prognosis in acute liver failure [J].

Polson, Julie .

SEMINARS IN LIVER DISEASE, 2008, 28 (02) :218-225

[7]

Characteristics of acute and sub-acute liver failure in China: nomination, classification and interval [J].

Liu, Qing ;

Liu, Zheng ;

Wang, Tailing ;

Wang, Qingguo ;

Shi, Xiaohong ;

Dao, Wenbin .

JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY, 2007, 22 (12) :2101-2106

[8]

Prognostic models including the Child–Pugh; MELD and Mayo risk scores—where are we and where should we go?.[J].Erik Christensen.Journal of Hepatology.2004, 2

[9]

Cirrhosis as a Risk Factor for Sepsis and Death.[J].Marilyn G. Foreman;David M. Mannino;Marc Moss.Chest.2003, 3

[10]

Acute liver failure: Targeted artificial and hepatocyte-based support of liver regeneration and reversal of multiorgan failure.[J].Stephen M. Riordan;Roger Williams.Journal of Hepatology.2000,

← 1 →