阴离子转运蛋白OAT1和OAT3与药物代谢相互影响的研究进展

被引：8

作者：

贾超 ^{[1
]}

魏敏吉 ^{[2
]}

赵秀丽 ^{[1
]}

机构：

[1] 首都医科大学附属北京同仁医院药物临床试验机构

[2] 北京大学第一医院临床药理研究所

来源：

中国临床药理学杂志 | 2010年 / 26卷 / 12期

关键词：

阴离子转运蛋白; 药物转运; 毒性;

D O I：

10.13699/j.cnki.1001-6821.2010.12.010

中图分类号：

R96 [药理学];

学科分类号：

100706 [药理学];

摘要：

阴离子转运蛋白(OAT)OAT1与OAT3同属SLC22A家族,主要在近端肾小管上皮细胞基底侧膜表达,在肝脏、肠和大脑亦有分布。它们介导有机阴离子进入其分布的细胞,进而参与多种药物在肾脏的分泌、重吸收和在体内的分布等。本文从OAT1和OAT3的分子生物学基础、主要功能、介导药物相互作用的机制和毒性的产生,研究其使用的模型、物种间存在的差异以及展望等。

引用

页码：957 / 960

页数：4

共 12 条

[1]

Drug interaction between celecoxib and methotrexate in organic anion transporter 3–transfected renal cells and in rats in vivo.[J].Akimitsu Maeda;Shuichi Tsuruoka;Kentarou Ushijima;Yoshikatsu Kanai;Hitoshi Endou;Kazuyuki Saito;Etsuko Miyamoto;Akio Fujimura.European Journal of Pharmacology.2010, 1

[2]

Low doses of ochratoxin A upregulate the protein expression of organic anion transporters Oat1, Oat2, Oat3 and Oat5 in rat kidney cortex [J].

Zlender, Vilim ;

Breljak, Davorka ;

Ljubojevic, Marija ;

Flajs, Dubravka ;

Balen, Daniela ;

Brzica, Hrvoje ;

Domijan, Ana-Marija ;

Peraica, Maja ;

Fuchs, Radovan ;

Anzai, Naohiko ;

Sabolic, Ivan .

TOXICOLOGY AND APPLIED PHARMACOLOGY, 2009, 239 (03) :284-296

[3]

Renal organic anion transporters OAT1 and OAT3 mediate the cellular accumulation of 5-sulfooxymethylfurfural, a reactive, nephrotoxic metabolite of the Maillard product 5-hydroxymethylfurfural [J].

Bakhiya, Nadiya ;

Monien, Bernhard ;

Frank, Heinz ;

Seidel, Albrecht ;

Glatt, Hansruedi .

BIOCHEMICAL PHARMACOLOGY, 2009, 78 (04) :414-419

[4]

Molecular evidence for an involvement of organic anion transporters (OATs) in aristolochic acid nephropathy.[J].Nadiya Bakhiya;Volker M. Arlt;Andrew Bahn;Gerhard Burckhardt;David H. Phillips;Hansruedi Glatt.Toxicology.2009, 1

[5]

Interaction and transport characteristics of mycophenolic acid and its glucuronide via human organic anion transporters hOAT1 and hOAT3 [J].

Uwai, Yuichi ;

Motohashi, Hideyuki ;

Tsuji, Yoshie ;

Ueo, Harumasa ;

Katsura, Toshiya ;

Inui, Ken-ichi .

BIOCHEMICAL PHARMACOLOGY, 2007, 74 (01) :161-168

[6]

Primary porcine proximal tubular cells as a model for transepithelial drug transport in human kidney.[J].Philipp Schlatter;Heike Gutmann;Juergen Drewe.European Journal of Pharmaceutical Sciences.2006, 1

[7]

Alterations in trans porter expression in liver, kidney, and duodenum after targeted disruption of the transcription factor HNF1α [J].