淀粉样β-蛋白在阿尔茨海默病突触可塑性中的作用

被引：11

作者：

张锦辉

郑琳琳

机构：

[1] 辽东学院医学院

来源：

辽东学院学报(自然科学版) | 2014年 / 21卷 / 02期

关键词：

阿尔茨海默病; 淀粉样β-蛋白; 突触可塑性;

D O I：

10.14168/j.issn.1673-4939.2014.02.010

中图分类号：

R749.16 [];

学科分类号：

摘要：

阿尔茨海默病是老年痴呆的常见类型,与年龄密切相关,目前AD的确切发病机制仍不十分清楚。AD发生后脑内出现老年斑,其核心成分为淀粉样β-蛋白(amyloidβ-peptide,Aβ)。Aβ在脑内的异常沉积导致突触可塑性降低,影响海马长时程增强过程。研究表明Aβ发挥神经毒性作用主要是其寡聚体,如Aβ1-40和Aβ1-42等,使N-甲基-D-天冬氨酸(NMDA)的受体失活,导致NMDA受体介导的谷氨酸异常增高,最终体现为学习记忆能力下降。

引用

页码：95 / 98

页数：4

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