基于核磁共振的代谢组学研究进展

被引:16
作者
赵剑宇
颜贤忠
机构
[1] 军事医学科学院国家生物医学分析中心,军事医学科学院国家生物医学分析中心北京,北京
关键词
核磁共振; 代谢组学; 毒理学; 功能基因组学;
D O I
10.13220/j.cnki.jipr.2004.05.016
中图分类号
R445.2 [核磁共振成像];
学科分类号
100207 ;
摘要
基于核磁共振技术的代谢组学研究 ,是近几年发展起来的一种新的“组学”技术。它主要是利用生物体液的核磁共振谱图所提供的生物体内全部小分子代谢物的丰富信息 ,通过对这些信息的多元统计分析和模式识别处理 ,了解相关生物体在功能基因组学、病理生理学、药理毒理学等方面的状况及动态变化 ,以及它们所揭示的生物学意义 ,并从分子水平来认识生命运动的规律。本文综述了核磁共振技术在代谢组学方面的研究进展。
引用
收藏
页码:308 / 312+321 +321
页数:6
相关论文
共 13 条
[1]  
Metabonomic applications in toxicity screening and disease diagnosis. Shockcor JP,Holmes E. Current Topics in Medicinal Chemistry . 2002
[2]  
An NMR-based metabonomic approach to investigate the biochemical consequences of genetic strain differences: application to the C57BL10J and Alpk: ApfCD mouse. Gavaghan CL,Holmes E,Lenz E,et al. FEBS Letters . 2000
[3]  
Proteomics: one small step for a digital computer, one giant leap for humankind. Geisow MJ. Nature Biotechnology . 1998
[4]  
Beyond genomics. Fell DA. Trends in Genetics . 2001
[5]  
Earthworm species of the genus Eisenia can be phenotypically differentiated by metabolic profiling. Bundy JG,Spurgeon DJ,Svendsen C. et al. FEBS Letters . 2002
[6]  
A functional genomics strategy that uses metabolome data to reveal the phenotype of silent mutations. Raamsdonk LM,Teusink B,Broadhurst D,et al. Nature Biotechnology . 2001
[7]  
Key challenges for toxicologists in the 21st Century. Smith LL. Trends in Pharmacological Sciences . 2001
[8]  
Nuclear magnetic resonance spectroscopic and principal components analysis investigations into biochemical effect of three model hepatotoxins. Beckwith-Hall BM,Nicholson JK,Nicholls AW,et al. Chemical Research in Toxicology . 1998
[9]  
Cluster analysis and display of genome-wide expression patterns. Eisen MB,Spellman PT,Brown PO,et al. Proceedings of the National Academy of Sciences of the United States of America . 1998
[10]  
Metabonomics: a platform for studying drug toxicity and gene function. Nicholson JK,Connelly J,Lindon JC,et al. Nature Reviews Drug Discovery . 2002