GM对高血压大鼠脑缺血再灌注后DNA损伤修复的影响

被引：16

作者：

娄季宇 ^{[1
]}

王景涛 ^{[2
]}

白宏英 ^{[1
]}

杨霄鹏 ^{[1
]}

李建章 ^{[1
]}

机构：

[1] 郑州大学第二附属医院神经内科

[2] 南京医科大学附属南京第一医院神经内科

来源：

中国实用神经疾病杂志 | 2006年 / 01期

关键词：

神经节苷脂; 缺血再灌注;

D O I：

暂无

中图分类号：

R544.1 [高血压]; R743 [脑血管疾病];

学科分类号：

摘要：

目的探讨GM1对局灶性脑缺血再灌注后神经元凋亡作用的机制。方法运用双肾双夹法建立肾血管性高血压大鼠模型,采用线栓法制备高血压大鼠短暂性局灶性脑缺血再灌注模型,免疫组化法检测再灌注过程中鼠脑DNA损伤修复蛋白XRCC1、TUNEL法检测凋亡。结果与假手术组相比,脑缺血再灌注3h至24 h在缺血区皮质XRCC1表达出现显著减低(P<0.05);再灌注24h缺血区皮质神经细胞发生凋亡,神经细胞XRCC1的表达强度与凋亡呈负相关。GM1治疗后缺血区皮质XRCC1的表达显著升高,凋亡显著减少(P<0.05)。结论GM1通过提高肾血管性高血压大鼠局灶性脑缺血再灌注后神经细胞XRCC1的表达,发挥了抗神经细胞凋亡的作用。

引用

页码：2 / 4

页数：3

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