栀子苷治疗阿尔采末病及神经保护的分子机制研究进展

被引：39

作者：

王磊 ^{[1
,2
,3
,4
]}

辛文锋 ^{[1
,2
,3
,4
]}

张文生 ^{[1
,2
,3
,4
]}

机构：

[1] 北京师范大学地表过程与资源生态国家重点实验室

[2] 中药资源保护与利用北京市重点实验室

[3] 教育部资源药物工程研究中心

[4] 云南省三七生物技术与制药工程研究中心

来源：

中国药理学通报 | 2012年 / 05期

关键词：

阿尔采末病; β-淀粉样蛋白; 栀子苷; 京尼平; 神经保护; 分子机制;

D O I：

暂无

中图分类号：

R749.16 [];

学科分类号：

摘要：

阿尔采末病(AD)是一种中枢神经退行性疾病,以学习记忆和认知功能障碍为主要表现。Aβ毒性级联损伤是其核心病理之一。栀子苷是栀子的主要有效成分,其苷元为京尼平。实验研究表明,栀子苷和京尼平具有抗Aβ毒性损伤、抗氧化应激,抗内质网应激、抗炎症反应及促进神经生长作用。从分子作用机制角度综述近年来栀子苷及京尼平治疗AD和神经保护作用的有关文献,以期为栀子治疗AD提供借鉴。

引用

页码：604 / 607

页数：4

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